| Entry |
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| Name |
Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
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| Definition |
K19969 K19979 K19974 K20424 K20425 K20426 K20427 K20430 -- --
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| Diagram |
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| Orthology |
acbO; 2-epi-5-epi-valiolone 7-phosphate 2-epimerase [EC: 5.1.3.35] [RN: R11081] acbL; 2-epi-valiolone-7-phosphate 1-reductase [EC:1.1.1.-] [RN: R11243] acbN; cyclitol oxidoreductase [RN: R11244] acbU; 1-epi-valienol-7-phosphate kinase [EC:2.7.-.-] [RN: R11245] acbR; 1-epi-valienol 1,7-diphosphate adenylyltransferases [EC:2.7.7.-] [RN: R11246] acbS; glycosyltransferase AcbS [EC:2.4.-.-] [RN: R11247] |
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| Class |
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compounds
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| Pathway |
| map00525 | Acarbose and validamycin biosynthesis |
| map01110 | Biosynthesis of secondary metabolites |
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| Reaction |
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| Compound |
| C20956 | alpha-D-Sedoheptulopyranose 7-phosphate |
| C17692 | 2-epi-5-epi-Valiolone 7-phosphate |
| C17693 | 5-epi-Valiolone 7-phosphate |
| C21204 | 5-epi-Valiolol 7-phosphate |
| C21205 | 1-epi-Valienol 7-phosphate |
| C21206 | 1,7-diphospho-1-epi-valienol |
| C21207 | NDP-1-epi-valienol 7-phosphate |
| C04268 | dTDP-4-amino-4,6-dideoxy-D-glucose |
| C21208 | dTDP-acarviose-7-phosphate |
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| Reference |
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| Authors |
Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A |
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| Title |
The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism. |
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| Journal |
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| Reference |
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| Authors |
Rockser Y, Wehmeier UF |
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| Title |
The gac-gene cluster for the production of acarbose from Streptomyces glaucescens GLA.O: identification, isolation and characterization. |
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| Journal |
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| LinkDB |
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