KEGG   MODULE: M00861
Entry
M00861            Pathway   Module                                 
Name
beta-Oxidation, peroxisome, VLCFA
Definition
K00232 K12405 (K07513,K08764)
Diagram
M00861

Orthology
K00232  
acyl-CoA oxidase [EC:1.3.3.6] [RN:R07934 R07950]
K12405  
(3R)-3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.119] [RN:R07935 R07936 R07951 R07952]
K07513  
acetyl-CoA acyltransferase 1 [EC:2.3.1.16] [RN:R07937 R07953]
K08764  
sterol carrier protein 2 [EC:2.3.1.176] [RN:R07937 R07953]
Class
Pathway modules; Lipid metabolism; Fatty acid metabolism
Pathway
map01040  Biosynthesis of unsaturated fatty acids
map01212  Fatty acid metabolism
map01100  Metabolic pathways
Reaction
R07934  
R07935  
R07936  
R07937  
R07950  
R07951  
R07952  
R07953  
Compound
C16168  (6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA
C16374  (2E,6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosaheptaenoyl-CoA
C16375  (3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA
C16376  (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexaenoyl-CoA
C16169  (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoyl-CoA
C16172  (6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA
C16387  (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-CoA
C16388  (3R,6Z,9Z,12Z,15Z,18Z)-3-Hydroxytetracosapentaenoyl-CoA
C16389  (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapentaenoyl-CoA
C16173  (4Z,7Z,10Z,13Z,16Z)-Docosapentaenoyl-CoA
RModule
RM018  Beta oxidation in acyl-CoA degradation
Reference
PMID:11734571
  Authors
Ferdinandusse S, Denis S, Mooijer PA, Zhang Z, Reddy JK, Spector AA, Wanders RJ
  Title
Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid.
  Journal
J Lipid Res 42:1987-95 (2001)
Reference
PMID:26611709
  Authors
Waterham HR, Ferdinandusse S, Wanders RJ
  Title
Human disorders of peroxisome metabolism and biogenesis.
  Journal
Biochim Biophys Acta 1863:922-33 (2016)
DOI:10.1016/j.bbamcr.2015.11.015
LinkDB

DBGET integrated database retrieval system