KEGG   MODULE: M00866
Entry
M00866            Pathway   Module                                 
Name
KDO2-lipid A biosynthesis, Raetz pathway, non-LpxL-LpxM type
Definition
K00677 (K02535,K16363) K02536 (K03269,K09949) K00748 K00912 K02527 K02517 K09778
Diagram
M00866

Orthology
K00677  
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]
K02535  
lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108]
K16363  
lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59]
K02536  
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]
K03269  
lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54]
K09949  
lpxI; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54] [RN:R04549]  
K00748  
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]
K00912  
lpxK; tetraacyldisaccharide 4'-kinase [EC:2.7.1.130]
K02527  
kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15]
K02517  
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase/acyltransferase [EC:2.3.1.241 2.3.1.-]
K09778  
lpxJ; Kdo2-lipid IVA 3' secondary acyltransferase [EC:2.3.1.-]
Class
Pathway modules; Glycan metabolism; Lipopolysaccharide metabolism
Pathway
map00540  Lipopolysaccharide biosynthesis
map01100  Metabolic pathways
Reference
PMID:26934862
  Authors
Li H, Liao T, Debowski AW, Tang H, Nilsson HO, Stubbs KA, Marshall BJ, Benghezal M
  Title
Lipopolysaccharide Structure and Biosynthesis in Helicobacter pylori.
  Journal
Helicobacter 21:445-461 (2016)
DOI:10.1111/hel.12301
Reference
PMID:24580642
  Authors
Whitfield C, Trent MS
  Title
Biosynthesis and export of bacterial lipopolysaccharides.
  Journal
Annu Rev Biochem 83:99-128 (2014)
DOI:10.1146/annurev-biochem-060713-035600
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