KEGG   MODULE: M00880
Entry
M00880            Pathway   Module                                 
Name
Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor
Definition
((K03639 K03637),K20967) (K03635,K21142) (((K03831,K03638) K03750),K15376)
Diagram
M00880

Orthology
K03639  
GTP 3',8-cyclase [EC:4.1.99.22] [RN:R09394]
K03637  
cyclic pyranopterin monophosphate synthase [EC:4.6.1.17] [RN:R11372]
K20967  
GTP 3',8-cyclase / cyclic pyranopterin monophosphate synthase [EC:4.1.99.22 4.6.1.17] [RN:R09394 R11372]
K03635  
molybdopterin synthase catalytic subunit [EC:2.8.1.12] [RN:R09395]
K21142  
MoaE-MoaD fusion protein [EC:2.8.1.12] [RN:R09395]
K03831  
molybdopterin adenylyltransferase [EC:2.7.7.75] [RN:R09726]
K03638  
molybdopterin adenylyltransferase [EC:2.7.7.75] [RN:R09726]
K03750  
molybdopterin molybdotransferase [EC:2.10.1.1] [RN:R09735]
K15376  
gephyrin [EC:2.10.1.1 2.7.7.75] [RN:R09726 R09735]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00790  Folate biosynthesis
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C00044  GTP
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C18239  Precursor Z
C05924  Molybdopterin
C19848  Adenylated molybdopterin
C18237  Molybdoenzyme molybdenum cofactor
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
  Authors
Bevers LE, Hagedoorn PL, Santamaria-Araujo JA, Magalon A, Hagen WR, Schwarz G
  Title
Function of MoaB proteins in the biosynthesis of the molybdenum and tungsten cofactors.
  Journal
Biochemistry 47:949-56 (2008)
DOI:10.1021/bi7020487
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