KEGG   MODULE: M00936
Entry
M00936            Pathway   Module                                 
Name
Melatonin biosynthesis, plants, tryptophan => serotonin => melatonin
Definition
K01593 K24541 K22450 (K22588,K13066)
Diagram
M00936

Orthology
K01593  
aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105] [RN:R00685]
K24541  
tryptamine 5-hydroxylase [EC:1.14.14.186] [RN:R12659]
K22450  
aralkylamine N-acetyltransferase [EC:2.3.1.87] [RN:R02911]
K22588,K13066  
acetylserotonin O-methyltransferase [EC:2.1.1.4] [RN:R03130]
Class
Pathway modules; Amino acid metabolism; Aromatic amino acid metabolism
Pathway
map00380  Tryptophan metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R00685  
R12659  
R02911  
R03130  
Compound
C00078  L-Tryptophan
C00398  Tryptamine
C00780  Serotonin
C00978  N-Acetylserotonin
C01598  Melatonin
Reference
PMID:27600803
  Authors
Back K, Tan DX, Reiter RJ
  Title
Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts.
  Journal
J Pineal Res 61:426-437 (2016)
DOI:10.1111/jpi.12364
LinkDB

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