KEGG   MODULE: M00944
Entry
M00944            Pathway   Module                                 
Name
Morphine biosynthesis, (S)-reticuline => morphine
Definition
K22093 K13391 K13392 K13393 K01742 K14975 K14976 K13394
Diagram
M00944

Orthology
K22093  
1,2-dehydroreticuline synthase/reductase [EC:1.14.19.54 1.5.1.27] [RN:R03833 R04695]
K13391  
salutaridine synthase [EC:1.14.19.67] [RN:R04696]
K13392  
salutaridine reductase (NADPH) [EC:1.1.1.248] [RN:R04697]
K13393  
salutaridinol 7-O-acetyltransferase [EC:2.3.1.150] [RN:R04723]
K01742  
thebaine synthase [EC:4.2.99.24] [RN:R04769]
K14975  
codeine 3-O-demethylase [EC:1.14.11.32] [RN:R05127]
K14976  
thebaine 6-O-demethylase [EC:1.14.11.31] [RN:R03698]
K13394  
codeinone reductase [EC:1.1.1.247] [RN:R03592]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R03833  
R04695  
R04696  
R04697  
R04723  
R04769  
R05127  
R03698  
R03592  
Compound
C02105  (S)-Reticuline
C06167  1,2-Dehydroreticuline
C05178  (R)-Reticuline
C05179  Salutaridine
C05220  Salutaridinol
C05322  7-O-Acetylsalutaridinol
C06173  Thebaine
C06175  Oripavine
C01735  Morphinone
C01516  Morphine
Reference
PMID:24671624
  Authors
Beaudoin GA, Facchini PJ.
  Title
Benzylisoquinoline alkaloid biosynthesis in opium poppy.
  Journal
Planta 240:19-32 (2014)
DOI:10.1007/s00425-014-2056-8
LinkDB

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