KEGG   MODULE: M00981
Entry
M00981            Pathway   Module                                 
Name
Geissoschizine biosynthesis, tryptophan => geissoschizine
Definition
K01593 K01757 K12693 K23493
Diagram
M00981

Orthology
K01593  
L-tryptophan decarboxylase [EC:4.1.1.105] [RN:R00685]
K01757  
strictosidine synthase [EC:3.5.99.13] [RN:R03738]
K12693  
strictosidine beta-D-glucosidase [EC:3.2.1.105] [RN:R03820]
K23493  
geissoschizine synthase [EC:1.3.1.36] [RN:R03860]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00078  L-Tryptophan
C00398  Tryptamine
C01852  Secologanin
C03470  3-alpha(S)-Strictosidine
C03309  Strictosidine aglycone
C11678  Dialdehyde
C11679  4,21-Dehydrocorynantheine aldehyde
C03677  4,21-Dehydrogeissoschizine
C02151  (19E)-Geissoschizine
Reference
  Authors
Qu Y, Easson MEAM, Simionescu R, Hajicek J, Thamm AMK, Salim V, De Luca V
  Title
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine.
  Journal
Proc Natl Acad Sci U S A 115:3180-3185 (2018)
DOI:10.1073/pnas.1719979115
Reference
  Authors
Zhang J, Hansen LG, Gudich O, Viehrig K, Lassen LMM, Schrubbers L, Adhikari KB, Rubaszka P, Carrasquer-Alvarez E, Chen L, D'Ambrosio V, Lehka B, Haidar AK, Nallapareddy S, Giannakou K, Laloux M, Arsovska D, Jorgensen MAK, Chan LJG, Kristensen M, Christensen HB, Sudarsan S, Stander EA, Baidoo E, Petzold CJ, Wulff T, O'Connor SE, Courdavault V, Jensen MK, Keasling JD.
  Title
A microbial supply chain for production of the anti-cancer drug vinblastine.
  Journal
Nature 609:341-347 (2022)
DOI:10.1038/s41586-022-05157-3
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