KEGG   PATHWAY: map00790
Entry
map00790                    Pathway                                

Name
Folate biosynthesis
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
map00790  Folate biosynthesis
map00790

Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:map00790]
M00840  Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF [PATH:map00790]
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF [PATH:map00790]
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:map00790]
M00843  L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4 [PATH:map00790]
M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:map00790]
Disease
H00167  Phenylketonuria
H00213  Hypophosphatasia
H00831  Primary dystonia
H01197  Dihydrofolate reductase deficiency
H02311  Molybdenum cofactor deficiency
Other DBs
GO: 0046656
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
map00230  Purine metabolism
map00362  Benzoate degradation
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00670  One carbon pool by folate
map00680  Methane metabolism
KO pathway
ko00790   
LinkDB

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