| Entry |
|
|---|
| Name |
EVI-1 overexpression to TGF-beta signaling pathway
|
|---|
| Definition |
EVI1* -| SMAD3 == SMAD4 |
|---|
| Expanded |
2122v1 -| 4088 == 4089 |
|---|
| Class |
|
|---|
| Type |
Variant
|
|---|
| Pathway |
|
|---|
| Disease |
| H00004 | Chronic myeloid leukemia |
|
|---|
| Gene |
| 2122 | MECOM; MDS1 and EVI1 complex locus |
| 4088 | SMAD3; SMAD family member 3 |
| 4089 | SMAD4; SMAD family member 4 |
|
|---|
| Variant |
2122v1 (EVI1*) EVI1 overexpression
|
|---|
| Reference |
|
|---|
| Authors |
Mitani K. |
|---|
| Title |
Molecular mechanisms of leukemogenesis by AML1/EVI-1. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H. |
|---|
| Title |
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells. |
|---|
| Journal |
Blood 92:4003-12 (1998) |
|---|
| Reference |
|
|---|
| Authors |
Dong M, Blobe GC. |
|---|
| Title |
Role of transforming growth factor-beta in hematologic malignancies. |
|---|
| Journal |
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|---|
| LinkDB |
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|---|
