KEGG   NETWORK: N00149
Entry
N00149                      Network                                
Name
TLR3-IRF3 signaling pathway
Definition
TLR3 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> IRF3 -> (CREBBP,EP300) => IFNB1
  Expanded
7098 -> 148022 -> 7187 -> (9641+29110) -> 3661 -> (1387,2033) => 3456
Class
nt06517 TLR signaling
nt06263 Hepatocellular carcinoma
nt06162 Hepatitis B virus (HBV)
nt06163 Hepatitis C virus (HCV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04620  Toll-like receptor signaling pathway
Gene
7098  TLR3; toll like receptor 3
148022  TICAM1; toll like receptor adaptor molecule 1
7187  TRAF3; TNF receptor associated factor 3
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
29110  TBK1; TANK binding kinase 1
3661  IRF3; interferon regulatory factor 3
1387  CREBBP; CREB binding protein
2033  EP300; E1A binding protein p300
3456  IFNB1; interferon beta 1
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:20561711
  Authors
Gauzzi MC, Del Corno M, Gessani S
  Title
Dissecting TLR3 signalling in dendritic cells.
  Journal
Immunobiology 215:713-23 (2010)
DOI:10.1016/j.imbio.2010.05.008
Reference
PMID:20046508
  Authors
Boo KH, Yang JS
  Title
Intrinsic cellular defenses against virus infection by antiviral type I interferon.
  Journal
Yonsei Med J 51:9-17 (2010)
DOI:10.3349/ymj.2010.51.1.9
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