Entry |
|
Name |
HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
|
Definition |
(Tat,Nef) -> CASP8 -> BID -> (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3 |
Expanded |
(K19258,K22891) -> 841 -> 637 -> (581,578) -> 54205 == 317 -> 842 -> 836 |
Class |
nt06161 Human immunodeficiency virus 1 (HIV-1)
|
Type |
Pathogen
|
Pathway |
hsa05170 | Human immunodeficiency virus 1 infection |
|
Disease |
|
Gene |
637 | BID; BH3 interacting domain death agonist |
581 | BAX; BCL2 associated X, apoptosis regulator |
578 | BAK1; BCL2 antagonist/killer 1 |
54205 | CYCS; cytochrome c, somatic |
317 | APAF1; apoptotic peptidase activating factor 1 |
|
Perturbant |
K19258 (Tat) | tat; HIV-1 protein Tat |
K22891 (Nef) | nef; HIV-1 protein Nef |
|
Reference |
|
Authors |
Abbas W, Herbein G |
Title |
T-Cell Signaling in HIV-1 Infection. |
Journal |
|
Reference |
|
Authors |
Fevrier M, Dorgham K, Rebollo A |
Title |
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis. |
Journal |
|
Reference |
|
Authors |
Cummins NW, Badley AD |
Title |
Mechanisms of HIV-associated lymphocyte apoptosis: 2010. |
Journal |
|
Reference |
|
Authors |
Gougeon ML |
Title |
Apoptosis as an HIV strategy to escape immune attack. |
Journal |
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LinkDB |
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