KEGG   NETWORK: N00587
Entry
N00587                      Network                                
Name
HSV ICP27 to Nuclear export of mRNA
Definition
ICP27 -| SRPK1 -> SRSF1 -- NXF1
  Expanded
K19443 -| 6732 -> 6426 -- 10482
Class
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
6732  SRPK1; SRSF protein kinase 1
6426  SRSF1; serine and arginine rich splicing factor 1
10482  NXF1; nuclear RNA export factor 1
Perturbant
K19443 (ICP27)  UL54; Simplexvirus mRNA export factor
Reference
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
  Authors
Sciabica KS, Dai QJ, Sandri-Goldin RM
  Title
ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation.
  Journal
EMBO J 22:1608-19 (2003)
DOI:10.1093/emboj/cdg166
Reference
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
LinkDB

DBGET integrated database retrieval system