KEGG   NETWORK: N00873
Entry
N00873                      Network                                
Name
GnRH-GnRHR-PLCB-PKC signaling pathway
Definition
GNRH1/2 -> GNRHR -> (GNAQ,GNA11) -> PLCB -> (Ca2+,DAG) -> PKC -> RAF1 -> MEK -> ERK -> ELK1 => (LHB,CGA,FSHB)
  Expanded
(2796,2797) -> 2798 -> (2776,2767) -> (23236,5330,5331,5332) -> (C00076,C00165) -> (5578,5579,5582) -> 5894 -> (5604,5605) -> (5594,5595) -> 2002 => (3972,1081,2488)
Class
nt06323 KISS1-GnRH-LH/FSH-E2 signaling
Type
Reference
Pathway
hsa04912  GnRH signaling pathway
Gene
2796  GNRH1; gonadotropin releasing hormone 1
2797  GNRH2; gonadotropin releasing hormone 2
2798  GNRHR; gonadotropin releasing hormone receptor
2776  GNAQ; G protein subunit alpha q
2767  GNA11; G protein subunit alpha 11
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
2002  ELK1; ETS transcription factor ELK1
3972  LHB; luteinizing hormone beta polypeptide
1081  CGA; glycoprotein hormones, alpha polypeptide
2488  FSHB; follicle stimulating hormone subunit beta
Metabolite
C00076  Calcium cation
C00165  Diacylglycerol
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
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