KEGG   NETWORK: N01265
Entry
N01265                      Network                                

Name
EBV vIL10 to IL10R signaling
Definition
vIL10 -> (IL10RA+IL10RB)
  Expanded
K21533 -> (3587+3588)
Class
nt06150 Cytokine-cytokine receptor interaction (viruses)
Type
Pathogen
Pathway
hsa04061  Viral protein interaction with cytokine and cytokine receptor
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
3587  IL10RA; interleukin 10 receptor subunit alpha
3588  IL10RB; interleukin 10 receptor subunit beta
Perturbant
K21533 (vIL10)  vIL10; EBV viral interleukin 10
Reference
PMID:8992974
  Authors
Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J
  Title
The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.
  Journal
J Immunol 158:604-13 (1997)
Reference
  Authors
Yoon SI, Jones BC, Logsdon NJ, Walter MR
  Title
Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
  Journal
Structure 13:551-64 (2005)
DOI:10.1016/j.str.2005.01.016
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