 | | NETWORK: N01313 | |
Entry |
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Name |
Classical pathway of complement activation
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Definition |
((C1QA,C1QB,C1QC)+C1R+C1S)) -> (C2+C4) -> C3 -> (VSIG4,CR1,CR2,CR3,CR4,(C5+C6+C7+C8+C9)) |
Expanded |
((712,713,714)+715+716)) -> (717+(720,721)) -> 718 -> (11326,1378,1380,(3684+3689),(3687+3689),(727+729+730+(731,732,733)+735)) |
Class |
nt06136 Complement activation (viruses)
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Type |
Reference
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Pathway |
hsa04610 | Complement and coagulation cascades |
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Gene |
712 | C1QA; complement C1q A chain |
713 | C1QB; complement C1q B chain |
714 | C1QC; complement C1q C chain |
720 | C4A; complement C4A (Rodgers blood group) |
721 | C4B; complement C4B (Chido blood group) |
11326 | VSIG4; V-set and immunoglobulin domain containing 4 |
1378 | CR1; complement C3b/C4b receptor 1 (Knops blood group) |
1380 | CR2; complement C3d receptor 2 |
3684 | ITGAM; integrin subunit alpha M |
3689 | ITGB2; integrin subunit beta 2 |
3687 | ITGAX; integrin subunit alpha X |
731 | C8A; complement C8 alpha chain |
732 | C8B; complement C8 beta chain |
733 | C8G; complement C8 gamma chain |
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Reference |
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Authors |
Ricklin D, Lambris JD |
Title |
Complement in immune and inflammatory disorders: pathophysiological mechanisms. |
Journal |
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Reference |
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Authors |
Bohlson SS, O'Conner SD, Hulsebus HJ, Ho MM, Fraser DA |
Title |
Complement, c1q, and c1q-related molecules regulate macrophage polarization. |
Journal |
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LinkDB |
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