KEGG   NETWORK: N01313
Entry
N01313                      Network                                

Name
Classical pathway of complement activation
Definition
((C1QA,C1QB,C1QC)+C1R+C1S)) -> (C2+C4) -> C3 -> (VSIG4,CR1,CR2,CR3,CR4,(C5+C6+C7+C8+C9))
  Expanded
((712,713,714)+715+716)) -> (717+(720,721)) -> 718 -> (11326,1378,1380,(3684+3689),(3687+3689),(727+729+730+(731,732,733)+735))
Class
nt06136 Complement activation (viruses)
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Reference
Pathway
hsa04610  Complement and coagulation cascades
Gene
712  C1QA; complement C1q A chain
713  C1QB; complement C1q B chain
714  C1QC; complement C1q C chain
715  C1R; complement C1r
716  C1S; complement C1s
717  C2; complement C2
720  C4A; complement C4A (Rodgers blood group)
721  C4B; complement C4B (Chido blood group)
718  C3; complement C3
11326  VSIG4; V-set and immunoglobulin domain containing 4
1378  CR1; complement C3b/C4b receptor 1 (Knops blood group)
1380  CR2; complement C3d receptor 2
3684  ITGAM; integrin subunit alpha M
3689  ITGB2; integrin subunit beta 2
3687  ITGAX; integrin subunit alpha X
727  C5; complement C5
729  C6; complement C6
730  C7; complement C7
731  C8A; complement C8 alpha chain
732  C8B; complement C8 beta chain
733  C8G; complement C8 gamma chain
735  C9; complement C9
Reference
  Authors
Ricklin D, Lambris JD
  Title
Complement in immune and inflammatory disorders: pathophysiological mechanisms.
  Journal
J Immunol 190:3831-8 (2013)
DOI:10.4049/jimmunol.1203487
Reference
  Authors
Bohlson SS, O'Conner SD, Hulsebus HJ, Ho MM, Fraser DA
  Title
Complement, c1q, and c1q-related molecules regulate macrophage polarization.
  Journal
Front Immunol 5:402 (2014)
DOI:10.3389/fimmu.2014.00402
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