KEGG   NETWORK: N01322
Entry
N01322                      Network                                

Name
SARS-CoV-2 nsp6/13 and ORF7a/7b to IFN signaling pathway
Definition
(nsp6,nsp13,ORF7a,ORF7b) -| STAT2
  Expanded
(K25016,K25022,K24581,K24582) -| 6773
Class
nt06122 IFN signaling (viruses)
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Variant
Pathway
hsa05171  Coronavirus disease - COVID-19
Disease
H02398  COVID-19
Gene
6773  STAT2; signal transducer and activator of transcription 2
Perturbant
K25016 (nsp6)  nsp6; SARS coronavirus non-structural protein 6
K25022 (nsp13)  nsp13; SARS coronavirus helicase
K24581 (ORF7a)  7a; SARS coronavirus accessory protein 7a
K24582 (ORF7b)  7b; SARS coronavirus accessory protein 7b
Reference
  Authors
Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY
  Title
Evasion of Type I Interferon by SARS-CoV-2.
  Journal
Cell Rep 33:108234 (2020)
DOI:10.1016/j.celrep.2020.108234
Reference
  Authors
Yuen CK, Lam JY, Wong WM, Mak LF, Wang X, Chu H, Cai JP, Jin DY, To KK, Chan JF, Yuen KY, Kok KH
  Title
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists.
  Journal
Emerg Microbes Infect 9:1418-1428 (2020)
DOI:10.1080/22221751.2020.1780953
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