KEGG   NETWORK: N01360
Entry
N01360                      Network                                
Name
P4-PR-RAS-ERK signaling pathway
Definition
P4 -> (PGR+SRC) -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1
  Expanded
C00410 -> (5241+6714) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595
Class
nt06210 ERK signaling (cancer)
Type
Reference
Gene
5241  PGR; progesterone receptor
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
595  CCND1; cyclin D1
Metabolite
C00410  Progesterone
Reference
PMID:32867363
  Authors
Pedroza DA, Subramani R, Lakshmanaswamy R
  Title
Classical and Non-Classical Progesterone Signaling in Breast Cancers.
  Journal
Cancers (Basel) 12:2440 (2020)
DOI:10.3390/cancers12092440
Reference
PMID:18202149
  Authors
Faivre EJ, Daniel AR, Hillard CJ, Lange CA
  Title
Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors.
  Journal
Mol Endocrinol 22:823-37 (2008)
DOI:10.1210/me.2007-0437
Reference
PMID:29146555
  Authors
Boonyaratanakornkit V, Hamilton N, Marquez-Garban DC, Pateetin P, McGowan EM, Pietras RJ
  Title
Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer.
  Journal
Mol Cell Endocrinol 466:51-72 (2018)
DOI:10.1016/j.mce.2017.11.010
Reference
PMID:22649404
  Authors
Mani SK, Oyola MG
  Title
Progesterone signaling mechanisms in brain and behavior.
  Journal
Front Endocrinol (Lausanne) 3:7 (2012)
DOI:10.3389/fendo.2012.00007
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