KEGG   NETWORK: N01378
Entry
N01378                      Network                                
Name
AFB1 to DNA adducts
Definition
AFB1 -- (CYP3A4,CYP1A2) -> AFB1-exo-8,9-epoxide == DNA
  Expanded
C06800 -- (1576,1544) -> C19586 == C00039
Class
nt06250 DNA adduct formation (cancer)
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H00048  Hepatocellular carcinoma
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
Gene
1576  CYP3A4; cytochrome P450 family 3 subfamily A member 4
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2
Perturbant
C06800 (AFB1)  Aflatoxin B1
Metabolite
C19586  Aflatoxin B1-exo-8,9-epoxide
C00039  DNA
Reference
PMID:12435844
  Authors
Wild CP, Turner PC
  Title
The toxicology of aflatoxins as a basis for public health decisions.
  Journal
Mutagenesis 17:471-81 (2002)
DOI:10.1093/mutage/17.6.471
Reference
PMID:9275165
  Authors
Kobertz WR, Wang D, Wogan GN, Essigmann JM
  Title
An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot.
  Journal
Proc Natl Acad Sci U S A 94:9579-84 (1997)
DOI:10.1073/pnas.94.18.9579
Reference
PMID:8759017
  Authors
Bailey EA, Iyer RS, Harris TM, Essigmann JM
  Title
A viral genome containing an unstable aflatoxin B1-N7-guanine DNA adduct situated at a unique site.
  Journal
Nucleic Acids Res 24:2821-8 (1996)
DOI:10.1093/nar/24.14.2821
Reference
PMID:29794965
  Authors
Marchese S, Polo A, Ariano A, Velotto S, Costantini S, Severino L
  Title
Aflatoxin B1 and M1: Biological Properties and Their Involvement in Cancer Development.
  Journal
Toxins (Basel) 10:E214 (2018)
DOI:10.3390/toxins10060214
LinkDB

DBGET integrated database retrieval system