KEGG   NETWORK: N01385
Entry
N01385                      Network                                
Name
VC to DNA adducts
Definition
VC -- CYP2E1 -> CEO -- DNA
  Expanded
C06793 -- 1571 -> C20303 -- C00039
Class
nt06250 DNA adduct formation
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H01557  Hepatic angiosarcoma
Gene
1571  CYP2E1; cytochrome P450 family 2 subfamily E member 1
Perturbant
C06793 (VC)  Vinyl chloride
Metabolite
C20303  Chloroethylene oxide
C00039  DNA
Reference
  Authors
Swenberg JA, Lu K, Moeller BC, Gao L, Upton PB, Nakamura J, Starr TB
  Title
Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment.
  Journal
Toxicol Sci 120 Suppl 1:S130-45 (2011)
DOI:10.1093/toxsci/kfq371
Reference
  Authors
Bolt HM
  Title
Vinyl chloride-a classical industrial toxicant of new interest.
  Journal
Crit Rev Toxicol 35:307-23 (2005)
DOI:10.1080/10408440490915975
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