KEGG   NETWORK: N01398
Entry
N01398                      Network                                
Name
Pentachlorophenol to CYP-mediated metabolism
Definition
PCP -- CYP1A2 -> TCHQ -> Superoxide
  Expanded
C02575 -- 1544 -> C03434 -> C00704
Class
nt06251 CYP-mediated ROS formation
Type
Env factor
Pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
Disease
H02418  Non-Hodgkin lymphoma
H00010  Multiple myeloma
Gene
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2
Perturbant
C02575 (PCP)  Pentachlorophenol
Metabolite
C03434  Tetrachlorohydroquinone
C00704  Superoxide
Reference
  Journal
Pentachlorophenol and Some Related Compounds(2019)
Reference
  Authors
Zhu BZ, Shan GQ
  Title
Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals.
  Journal
Chem Res Toxicol 22:969-77 (2009)
DOI:10.1021/tx900030v
LinkDB

DBGET integrated database retrieval system