| Entry |
|
|---|
| Name |
Pentachlorophenol to CYP-mediated metabolism
|
|---|
| Definition |
PCP -- CYP1A2 -> TCHQ -> Superoxide |
|---|
| Expanded |
C02575 -- 1544 -> C03434 -> C00704 |
|---|
| Class |
nt06251 CYP-mediated ROS formation (cancer)
|
|---|
| Type |
Env factor
|
|---|
| Pathway |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
|
|---|
| Disease |
|
|---|
| Gene |
| 1544 | CYP1A2; cytochrome P450 family 1 subfamily A member 2 |
|
|---|
| Perturbant |
| C02575 (PCP) | Pentachlorophenol |
|
|---|
| Metabolite |
| C03434 | Tetrachlorohydroquinone |
|
|---|
| Reference |
|
|---|
| Journal |
Pentachlorophenol and Some Related Compounds (2019) |
|---|
| Reference |
|
|---|
| Authors |
Zhu BZ, Shan GQ |
|---|
| Title |
Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals. |
|---|
| Journal |
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|---|
| LinkDB |
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