KEGG   NETWORK: N01509
Entry
N01509                      Network                                
Name
Intrinsic pathway of coagulation cascade, F8 activation
Definition
(F8+VWF) -- (F10a,F2a) -> F8a -> (F9a+F8a)
  Expanded
(2157+7450) -- (C01065,C00752) -> C04001 -> (C03259+C04001)
Class
nt06514 Coagulation cascade
Type
Reference
Pathway
hsa04610  Complement and coagulation cascades
Gene
2157  F8; coagulation factor VIII
7450  VWF; von Willebrand factor
Metabolite
C01065  Coagulation factor Xa
C00752  Thrombin
C04001  Coagulation factor VIIIa
C03259  Coagulation factor IXa
Reference
  Authors
Samuelson Bannow B, Recht M, Negrier C, Hermans C, Berntorp E, Eichler H, Mancuso ME, Klamroth R, O'Hara J, Santagostino E, Matsushita T, Kessler C
  Title
Factor VIII: Long-established role in haemophilia A and emerging evidence beyond haemostasis.
  Journal
Blood Rev 35:43-50 (2019)
DOI:10.1016/j.blre.2019.03.002
Reference
  Authors
Palta S, Saroa R, Palta A
  Title
Overview of the coagulation system.
  Journal
Indian J Anaesth 58:515-23 (2014)
DOI:10.4103/0019-5049.144643
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