 | | NETWORK: N01858 | |
| Entry |
|
|---|
| Name |
EFNB1-MAPT axon guidance signaling
|
|---|
| Definition |
EFNB1 -> EPHB2 -> PI3K -> PIP3 -> AKT -| GSK3B -> MAPT == (TUBA+TUBB) |
|---|
| Expanded |
1947 -> 2048 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 2932 -> 4137 == ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688)) |
|---|
| Class |
|
|---|
| Type |
Reference
|
|---|
| Gene |
| 2048 | EPHB2; EPH receptor B2 |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 2932 | GSK3B; glycogen synthase kinase 3 beta |
| 4137 | MAPT; microtubule associated protein tau |
| 7846 | TUBA1A; tubulin alpha 1a |
| 10376 | TUBA1B; tubulin alpha 1b |
| 84790 | TUBA1C; tubulin alpha 1c |
| 7278 | TUBA3C; tubulin alpha 3c |
| 113457 | TUBA3D; tubulin alpha 3d |
| 112714 | TUBA3E; tubulin alpha 3e |
| 7277 | TUBA4A; tubulin alpha 4a |
| 51807 | TUBA8; tubulin alpha 8 |
| 203068 | TUBB; tubulin beta class I |
| 81027 | TUBB1; tubulin beta 1 class VI |
| 7280 | TUBB2A; tubulin beta 2A class IIa |
| 347733 | TUBB2B; tubulin beta 2B class IIb |
| 10381 | TUBB3; tubulin beta 3 class III |
| 10382 | TUBB4A; tubulin beta 4A class IVa |
| 10383 | TUBB4B; tubulin beta 4B class IVb |
| 84617 | TUBB6; tubulin beta 6 class V |
| 347688 | TUBB8; tubulin beta 8 class VIII |
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Sanchez-Huertas C, Herrera E |
|---|
| Title |
With the Permission of Microtubules: An Updated Overview on Microtubule Function During Axon Pathfinding. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Jiang J, Wang ZH, Qu M, Gao D, Liu XP, Zhu LQ, Wang JZ |
|---|
| Title |
Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3beta. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Zhang L, Qi Z, Li J, Li M, Du X, Wang S, Zhou G, Xu B, Liu W, Xi S, Xu Z, Deng Y |
|---|
| Title |
Roles and Mechanisms of Axon-Guidance Molecules in Alzheimer's Disease. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
|
|