KEGG   REACTION: R00014
Entry
R00014                      Reaction                               
Name
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Definition
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
Equation
C00022 + C00068 <=> C05125 + C00011
Comment
2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699), subsequently R03270
TPP-dependent enzymatic reaction (see R00006), subsequently R03050
TPP-dependent enzymatic reaction (see R00226), subsequently R04672
TPP-dependent enzymatic reaction (see R00224), subsequently R00755
TPP-dependent enzymatic reaction (see R08648), subsequently R04673
Reaction class
RC00027  C00068_C05125
RC02744  C00022_C05125
Enzyme
1.2.4.1         2.2.1.6         4.1.1.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
rn00785  Lipoic acid metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1
     R00014  Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
 2. Transferase reactions
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.6
     R00014  Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.1
     R00014  Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K01568  pyruvate decarboxylase [EC:4.1.1.1]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
LinkDB

KEGG   RCLASS: RC00027
Entry
RC00027                     RClass                                 
Definition
C8x-C8y:*-C1c:N5y+S2x-N5y+S2x
Reactant pair
C00068_C05125    C00068_C05381    C00068_C13378
C00068_C15974    C00068_C15976    C00068_C15978
C00068_C21017    C00068_C22667
Related class
Reaction
R00014 R00621 R00755 R03050 R03270 R03316 R04672 R04673
R06861 R06862 R06863 R07599 R07600 R07601 R07602 R07603
R07604 R10996 R10997 R13166 R13167
Enzyme
1.2.4.1         1.2.4.2         1.2.4.4         1.2.4.-         
2.2.1.1         2.2.1.3         2.2.1.6         4.1.1.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn00785  Lipoic acid metabolism
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K01568  pyruvate decarboxylase [EC:4.1.1.1]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
K15791  2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]

KEGG   RCLASS: RC02744
Entry
RC02744                     RClass                                 
Definition
C1c-C5a:C8y+*-*+C6a:C1a+O1a-C1a+O5a
Reactant pair
C00022_C05125
Related class
Reaction
R00014
Enzyme
1.2.4.1         2.2.1.6         4.1.1.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
rn00785  Lipoic acid metabolism
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K01568  pyruvate decarboxylase [EC:4.1.1.1]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]

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