KEGG   REACTION: R00102
Entry
R00102                      Reaction                               
Name
NAD+ glycohydrolase
Definition
NAD+ + H2O <=> Nicotinamide + ADP-ribose
Equation
Reaction class
RC00033  C00003_C00153
RC00485  C00003_C00301
Enzyme
3.2.2.5         3.2.2.6         3.5.1.-
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.2  Glycosylases
   3.2.2  Hydrolysing N-glycosyl compounds
    3.2.2.5
     R00102  NAD+ + H2O <=> Nicotinamide + ADP-ribose
    3.2.2.6
     R00102  NAD+ + H2O <=> Nicotinamide + ADP-ribose
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.-
     R00102  NAD+ + H2O <=> Nicotinamide + ADP-ribose
Orthology
K01242  ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20]
K18152  ADP-ribosyl cyclase 2 [EC:3.2.2.6 2.4.99.20]
K18153  NAD+ glycohydrolase [EC:3.2.2.5]
K19980  ADP-ribosyltransferase 2 / NAD+ glycohydrolase [EC:2.4.2.31 3.2.2.5]
K27536  NAD(+) hydrolase SARM1 [EC:3.2.2.6]
Reference
1  [PMID:19001417]
  Authors
Belenky P, Christensen KC, Gazzaniga F, Pletnev AA, Brenner C.
  Title
Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+  metabolism.
  Journal
J Biol Chem 284:158-64 (2009)
DOI:10.1074/jbc.M807976200
Other DBs
RHEA: 16304
LinkDB

KEGG   RCLASS: RC00033
Entry
RC00033                     RClass                                 
Definition
N5x-N5y:*-C1y:C8x+C8x-C8x+C8x
Reactant pair
Related class
Reaction
Enzyme
2.3.1.286       2.4.1.17        2.4.1.196       2.4.2.1         
2.4.2.2         2.4.2.12        2.4.2.21        2.4.2.30        
2.4.2.31        2.4.2.36        2.4.2.37        2.4.2.55        
2.4.2.59        2.4.2.60        2.4.99.20       3.2.2.3         
3.2.2.5         3.2.2.6         3.2.2.8         3.2.2.10        
3.2.2.14        3.5.1.-         6.3.4.21
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Orthology
K00699  glucuronosyltransferase [EC:2.4.1.17]
K00763  nicotinate phosphoribosyltransferase [EC:6.3.4.21]
K00768  nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21]
K01240  uridine nucleosidase [EC:3.2.2.3]
K01242  ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20]
K03146  cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]
K03462  nicotinamide phosphoribosyltransferase [EC:2.4.2.12]
K03783  purine-nucleoside phosphorylase [EC:2.4.2.1]
K03784  purine-nucleoside phosphorylase [EC:2.4.2.1]
K11121  NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
K11411  NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K11412  NAD-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]
K11413  NAD-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]
K11414  NAD-dependent protein deacetylase/lipoamidase sirtuin 4 [EC:2.3.1.286 2.3.1.313]
K11415  NAD-dependent protein deacetylase sirtuin 5 [EC:2.3.1.286]
K11416  NAD-dependent protein deacetylase sirtuin 6 [EC:2.3.1.286]
K11417  NAD-dependent protein deacetylase sirtuin 7 [EC:2.3.1.286]
K12410  NAD-dependent protein deacetylase/lipoamidase [EC:2.3.1.286 2.3.1.313]
K18152  ADP-ribosyl cyclase 2 [EC:3.2.2.6 2.4.99.20]
K18153  NAD+ glycohydrolase [EC:3.2.2.5]
K19980  ADP-ribosyltransferase 2 / NAD+ glycohydrolase [EC:2.4.2.31 3.2.2.5]
K22699  sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]
K27536  NAD(+) hydrolase SARM1 [EC:3.2.2.6]

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