KEGG   REACTION: R00209
Entry
R00209                      Reaction                               
Name
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating);
pyruvate dehydrogenase complex
Definition
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Equation
Comment
multienzyme system: ec 1.2.4.1, ec 2.3.1.12 and ec 1.8.1.4
multi-step reaction (see R01699+R02569+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00024
RC02742  C00022_C00024
Enzyme
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.104
     R00209  Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00627  pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
Other DBs
RHEA: 28045
LinkDB

KEGG   REACTION: R00210
Entry
R00210                      Reaction                               
Name
pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
Definition
Pyruvate + CoA + NADP+ <=> Acetyl-CoA + CO2 + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00024
RC02742  C00022_C00024
Enzyme
Pathway
rn01210  2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.51
     R00210  Pyruvate + CoA + NADP+ <=> Acetyl-CoA + CO2 + NADPH + H+
Other DBs
RHEA: 17428
LinkDB

KEGG   REACTION: R01196
Entry
R01196                      Reaction                               
Name
pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)
Definition
2 Reduced ferredoxin + Acetyl-CoA + CO2 + 2 H+ <=> 2 Oxidized ferredoxin + Pyruvate + CoA
Equation
Reaction class
RC00004  C00010_C00024
RC02742  C00022_C00024
Enzyme
1.2.7.1         1.2.7.11
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
rn00650  Butanoate metabolism
rn00680  Methane metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
M00374  Dicarboxylate-hydroxybutyrate cycle
M00620  Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.7  With an iron-sulfur protein as acceptor
    1.2.7.1
     R01196  2 Reduced ferredoxin + Acetyl-CoA + CO2 + 2 H+ <=> 2 Oxidized ferredoxin + Pyruvate + CoA
    1.2.7.11
     R01196  2 Reduced ferredoxin + Acetyl-CoA + CO2 + 2 H+ <=> 2 Oxidized ferredoxin + Pyruvate + CoA
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.2.7.11
   R10516
    R01196  Pyruvate <=> Acetyl-CoA
Overall reaction [br08210.html]
 Carbon fixation
  R01196
Orthology
K00169  pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
K00170  pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
K00171  pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
K00172  pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
K00174  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
K00175  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
K03737  pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]
Other DBs
RHEA: 12768 44143
LinkDB

KEGG   RCLASS: RC02742
Entry
RC02742                     RClass                                 
Definition
C5a-C5a:C6a+*-*+S2a:C1a+O5a-C1a+O5a
Reactant pair
Related class
Reaction
Enzyme
1.2.1.104       1.2.3.6         1.2.7.1         1.2.7.11        
1.2.7.-         2.3.1.54
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
rn00650  Butanoate metabolism
rn00680  Methane metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
RModule
RM044  2-Oxocarboxylic acid conversion to its CoA derivative
RM903  Oxidative decarboxylation of 2-oxoacid to form its CoA derivative
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00169  pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
K00170  pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
K00171  pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
K00172  pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
K00174  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
K00175  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00627  pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
K00656  formate C-acetyltransferase [EC:2.3.1.54]
K03737  pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]

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