KEGG   REACTION: R00245
Entry
R00245                      Reaction                               
Name
L-glutamate gamma-semialdehyde:NAD+ oxidoreductase
Definition
L-Glutamate 5-semialdehyde + NAD+ + H2O <=> L-Glutamate + NADH + H+
Equation
C01165 + C00003 + C00001 <=> C00025 + C00004 + C00080
Comment
the second step of two-step reaction (see R00707, R03314+R00245)
following after R03314
Reaction class
RC00001  C00003_C00004
RC00080  C00025_C01165
Enzyme
1.2.1.88
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Module
M00970  Proline degradation, proline => glutamate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.88
     R00245  L-Glutamate 5-semialdehyde + NAD+ + H2O <=> L-Glutamate + NADH + H+
Orthology
K00294  1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]
K13821  RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
Other DBs
RHEA: 30238
LinkDB

KEGG   REACTION: R13148
Entry
R13148                      Reaction                               
Definition
L-Glutamate 5-semialdehyde + NADP+ + H2O <=> L-Glutamate + NADPH + H+
Equation
C01165 + C00006 + C00001 <=> C00025 + C00005 + C00080
Comment
the second step of two-step reaction (see R00708, R03314+R13148)
following after R03314
Reaction class
RC00080  C00025_C01165
Enzyme
1.2.1.88
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Module
M00970  Proline degradation, proline => glutamate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.88
     R13148  L-Glutamate 5-semialdehyde + NADP+ + H2O <=> L-Glutamate + NADPH + H+
Orthology
K00294  1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]
K13821  RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
Other DBs
RHEA: 68415
LinkDB

KEGG   RCLASS: RC00080
Entry
RC00080                     RClass                                 
Definition
C4a-C6a:*-O6a:C1b+O4a-C1b+O6a
Reactant pair
C00025_C01165    C00026_C00433    C00042_C00232
C00049_C00441    C00083_C05989    C00099_C05665
C00160_C00266    C00222_C00383    C00249_C00517
C00334_C00555    C00347_C00609    C00431_C12455
C00489_C03273    C00576_C00719    C00593_C14179
C00601_C07086    C00609_C00638    C00637_C00954
C00642_C03765    C00956_C04076    C01035_C02647
C01149_C01181    C01161_C04043    C02835_C05130
C02892_C05856    C02946_C05936    C03167_C05682
C04022_C23002    C05581_C05582    C05634_C05635
C05654_C05655    C05827_C05828    C05931_C05932
C06102_C06104    C06108_C15488    C06144_C06145
C06754_C06755    C07645_C07646    C09848_C16462
C11384_C16462    C15700_C15767    C16556_C16557
C16610_C16612    C19567_C19569    C19614_C19615
C19617_C19618    C19624_C19625    C19682_C19683
C19945_C19946    C21697_C21699
 » show all
Related class
Reaction
R00072 R00245 R00264 R00713 R00714 R00744 R00904 R01333
R01604 R01607 R01704 R01986 R02039 R02401 R02536 R02537
R02549 R02565 R02566 R02678 R02681 R02695 R02697 R03102
R03103 R03177 R03283 R03300 R03302 R04065 R04251 R04888
R04889 R04903 R04904 R04916 R04917 R04996 R05049 R05050
R05099 R05119 R05120 R05286 R06980 R07156 R07417 R07418
R08087 R08096 R08211 R08282 R08283 R08292 R08349 R09457
R09458 R09459 R09554 R09805 R09820 R10105 R10551 R10982
R11679 R11768 R11809 R12215 R13037 R13148 R13451
Enzyme
1.1.3.17        1.1.3.23        1.2.1.3         1.2.1.4         
1.2.1.5         1.2.1.8         1.2.1.15        1.2.1.16        
1.2.1.19        1.2.1.20        1.2.1.21        1.2.1.24        
1.2.1.26        1.2.1.29        1.2.1.31        1.2.1.39        
1.2.1.47        1.2.1.48        1.2.1.53        1.2.1.54        
1.2.1.63        1.2.1.69        1.2.1.71        1.2.1.73        
1.2.1.77        1.2.1.79        1.2.1.83        1.2.1.88        
1.2.1.91        1.2.1.95        1.2.1.99        1.2.1.-         
1.2.3.1         1.2.3.7         1.2.-.-         1.14.14.3       
1.14.14.49
Pathway
rn00040  Pentose and glucuronate interconversions
rn00053  Ascorbate and aldarate metabolism
rn00071  Fatty acid degradation
rn00073  Cutin, suberine and wax biosynthesis
rn00250  Alanine, aspartate and glutamate metabolism
rn00260  Glycine, serine and threonine metabolism
rn00310  Lysine degradation
rn00330  Arginine and proline metabolism
rn00340  Histidine metabolism
rn00350  Tyrosine metabolism
rn00360  Phenylalanine metabolism
rn00362  Benzoate degradation
rn00380  Tryptophan metabolism
rn00410  beta-Alanine metabolism
rn00430  Taurine and hypotaurine metabolism
rn00440  Phosphonate and phosphinate metabolism
rn00470  D-Amino acid metabolism
rn00625  Chloroalkane and chloroalkene degradation
rn00630  Glyoxylate and dicarboxylate metabolism
rn00640  Propanoate metabolism
rn00643  Styrene degradation
rn00650  Butanoate metabolism
rn00670  One carbon pool by folate
rn00730  Thiamine metabolism
rn00760  Nicotinate and nicotinamide metabolism
rn00770  Pantothenate and CoA biosynthesis
rn00930  Caprolactam degradation
rn00980  Metabolism of xenobiotics by cytochrome P450
rn00982  Drug metabolism - cytochrome P450
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
RModule
RM017  Ring cleavage via Baeyer-Villiger oxidation
RM025  Conversion of amino acid moiety to carboxyl group
Orthology
K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K00129  aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K00130  betaine-aldehyde dehydrogenase [EC:1.2.1.8]
K00135  succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
K00137  aminobutyraldehyde dehydrogenase [EC:1.2.1.19]
K00139  succinate-semialdehyde dehydrogenase [EC:1.2.1.24]
K00143  L-2-aminoadipate reductase [EC:1.2.1.95]
K00146  phenylacetaldehyde dehydrogenase [EC:1.2.1.39]
K00149  aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
K00157  aldehyde oxidase [EC:1.2.3.1]
K00206  phosphonoacetaldehyde dehydrogenase [EC:1.2.1.-]
K00294  1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]
K00494  alkanal monooxygenase alpha chain [EC:1.14.14.3]
K02618  oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase [EC:3.3.2.12 1.2.1.91]
K06447  succinylglutamic semialdehyde dehydrogenase [EC:1.2.1.71]
K07248  lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase [EC:1.2.1.22 1.2.1.21]
K08324  succinate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.24]
K09472  4-(gamma-glutamylamino)butanal dehydrogenase [EC:1.2.1.99]
K11817  indole-3-acetaldehyde oxidase [EC:1.2.3.7]
K12254  4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase [EC:1.2.1.54 1.2.1.-]
K13774  citronellol/citronellal dehydrogenase
K13775  citronellol/citronellal dehydrogenase
K13821  RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
K13877  2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26]
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K14519  NADP-dependent aldehyde dehydrogenase [EC:1.2.1.4]
K15514  3,4-dehydroadipyl-CoA semialdehyde dehydrogenase [EC:1.2.1.77]
K15786  aspartate-semialdehyde dehydrogenase [EC:1.2.1.-]
K15854  alkanal monooxygenase beta chain [EC:1.14.14.3]
K17755  choline oxidase [EC:1.1.3.17]
K17761  succinate-semialdehyde dehydrogenase, mitochondrial [EC:1.2.1.24]
K19588  2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26]
K19699  sulfoacetaldehyde dehydrogenase [EC:1.2.1.73]
K19700  3-succinoylsemialdehyde-pyridine dehydrogenase [EC:1.2.1.83]
K19962  6-oxohexanoate dehydrogenase [EC:1.2.1.63]
K22187  alpha-ketoglutaric semialdehyde dehydrogenase [EC:1.2.1.-]
K22417  benzaldehyde dehydrogenase (NAD+) / indole-3-acetaldehyde oxidase [EC:1.2.1.28 1.2.3.7]
K26061  L-aminoadipate-semialdehyde dehydrogenase

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