KEGG   REACTION: R00352
Entry
R00352                      Reaction                               
Name
acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
Definition
ATP + Citrate + CoA <=> ADP + Orthophosphate + Acetyl-CoA + Oxaloacetate
Equation
C00002 + C00158 + C00010 <=> C00008 + C00009 + C00024 + C00036
Comment
multi-step reaction (see R01322+R00354)
Reaction class
RC00002  C00002_C00008
RC00004  C00010_C00024
RC00067  C00036_C00158
Enzyme
2.3.3.8
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.8
     R00352  ATP + Citrate + CoA <=> ADP + Orthophosphate + Acetyl-CoA + Oxaloacetate
Overall reaction [br08210.html]
 Carbon fixation
  R00352
Orthology
K01648  ATP citrate (pro-S)-lyase [EC:2.3.3.8]
K15230  ATP-citrate lyase alpha-subunit [EC:2.3.3.8]
K15231  ATP-citrate lyase beta-subunit [EC:2.3.3.8]
Other DBs
RHEA: 21163
LinkDB

KEGG   REACTION: R01322
Entry
R01322                      Reaction                               
Name
citrate:CoA ligase (ADP-forming)
Definition
ATP + Citrate + CoA <=> ADP + Orthophosphate + (3S)-Citryl-CoA
Equation
C00002 + C00158 + C00010 <=> C00008 + C00009 + C00566
Comment
a part of multi-step reaction (see R00352, R01322+R00354)
Reaction class
RC00002  C00002_C00008
RC00004  C00010_C00566
RC00014  C00158_C00566
Enzyme
6.2.1.18
Pathway
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.18
     R01322  ATP + Citrate + CoA <=> ADP + Orthophosphate + (3S)-Citryl-CoA
Overall reaction [br08210.html]
 Carbon fixation
  R01322
Orthology
K15232  citryl-CoA synthetase large subunit [EC:6.2.1.18]
K15233  citryl-CoA synthetase small subunit
Other DBs
RHEA: 21475
LinkDB

KEGG   REACTION: R00354
Entry
R00354                      Reaction                               
Name
(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)
Definition
(3S)-Citryl-CoA <=> Acetyl-CoA + Oxaloacetate
Equation
C00566 <=> C00024 + C00036
Comment
a part of multi-step reaction (see R00352, R01322+R00354)
Reaction class
RC00067  C00036_C00566
RC00502  C00024_C00566
Enzyme
4.1.3.34
Pathway
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.34
     R00354  (3S)-Citryl-CoA <=> Acetyl-CoA + Oxaloacetate
Overall reaction [br08210.html]
 Carbon fixation
  R00354
Orthology
K15234  citryl-CoA lyase [EC:4.1.3.34]
Other DBs
RHEA: 20815
LinkDB

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