KEGG   REACTION: R00497
Entry
R00497                      Reaction                               
Name
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
Definition
ATP + gamma-L-Glutamyl-L-cysteine + Glycine <=> ADP + Orthophosphate + Glutathione
Equation
C00002 + C00669 + C00037 <=> C00008 + C00009 + C00051
Reaction class
RC00002  C00002_C00008
RC00096  C00037_C00051
RC00141  C00051_C00669
Enzyme
6.3.2.3
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00118  Glutathione biosynthesis, glutamate => glutathione
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.3
     R00497  ATP + gamma-L-Glutamyl-L-cysteine + Glycine <=> ADP + Orthophosphate + Glutathione
Orthology
K01920  glutathione synthase [EC:6.3.2.3]
K21456  glutathione synthase [EC:6.3.2.3]
Other DBs
RHEA: 13560
LinkDB

KEGG   RCLASS: RC00096
Entry
RC00096                     RClass                                 
Definition
N1a-N1b:*-C5a:C1b-C1b
Reactant pair
C00037_C00051    C00037_C01419    C00037_C01586
C00037_C01921    C00037_C02055    C00037_C02564
C00037_C05380    C00037_C05464    C00037_C05466
C00037_C05596    C00037_C05598    C00037_C05729
C00037_C05951    C00037_C16623    C00037_C21016
C00047_C02427    C00047_C02444    C00047_C02727
C00047_C04211    C00047_C05552    C00047_C20278
C00047_C21730    C00077_C00327    C00099_C00864
C00099_C01073    C00099_C02642    C00099_C03492
C00099_C04544    C00134_C00436    C00134_C02714
C00134_C03002    C00134_C10497    C00134_C15699
C00134_C18326    C00179_C02253    C00179_C04498
C00179_C18325    C00189_C04080    C00189_C11695
C00245_C05122    C00245_C05463    C00245_C05465
C00245_C05844    C00315_C01029    C00315_C05730
C00334_C02946    C00334_C15767    C00388_C04138
C00388_C05135    C00431_C03087    C00437_C15532
C00483_C02717    C00483_C20926    C00515_C22101
C00739_C19720    C00750_C16562    C00780_C00978
C00797_C01047    C00825_C03154    C00831_C01678
C01142_C21604    C01205_C21029    C01255_C02378
C01997_C02415    C02038_C03881    C02090_C05730
C02188_C20743    C02188_C21178    C02297_C03687
C02801_C03357    C03194_C06508    C03239_C05548
C03283_C06442    C03318_C04149    C03401_C04209
C03401_C20961    C03401_C22072    C03415_C18048
C03557_C05683    C03557_C21403    C04122_C06509
C04681_C04735    C04682_C04736    C04702_C04894
C04727_C04763    C04801_C04827    C05332_C06746
C05670_C06114    C05771_C05774    C05893_C17550
C05894_C17541    C05895_C17542    C06249_C06250
C06664_C17377    C06866_C16666    C15534_C15535
C16562_C16563    C16565_C16566    C16566_C16567
C16631_C16632    C17399_C20816    C17541_C17542
C17586_C18005    C18007_C18008    C20814_C20816
 » show all
Related class
Reaction
R00059 R00395 R00454 R00458 R00497 R00545 R00665 R00899
R00905 R00909 R01077 R01152 R01154 R01156 R01396 R01398
R01399 R01424 R01425 R01617 R01620 R01687 R01723 R01889
R01917 R01918 R01944 R01987 R02041 R02152 R02276 R02385
R02452 R02473 R02474 R02741 R02797 R02911 R02929 R02930
R02973 R03095 R03552 R03579 R03718 R03720 R03760 R03822
R03910 R03956 R03971 R03975 R03977 R03992 R04056 R04174
R04192 R04211 R04252 R04486 R04487 R04562 R04563 R04582
R04604 R04613 R04666 R04777 R04951 R04975 R05055 R05145
R05226 R05835 R05841 R06529 R06978 R07245 R07300 R07301
R07302 R07414 R07419 R07643 R08228 R08252 R08350 R08351
R08352 R08353 R08354 R08355 R08744 R08745 R08776 R08777
R08778 R08779 R08906 R08910 R08937 R09255 R09256 R09257
R09379 R09536 R09596 R10011 R10633 R10634 R10745 R10746
R10752 R10821 R10902 R10940 R10994 R11207 R11208 R11479
R11701 R11862 R12308 R12353 R12514 R12626
 » show all
Enzyme
2.1.3.3         2.1.3.6         2.1.3.8         2.1.3.9         
2.1.3.11        2.3.1.13        2.3.1.32        2.3.1.48        
2.3.1.57        2.3.1.58        2.3.1.64        2.3.1.65        
2.3.1.71        2.3.1.82        2.3.1.87        2.3.1.97        
2.3.1.108       2.3.1.110       2.3.1.138       2.3.1.178       
2.3.1.192       2.3.1.264       2.3.1.280       2.3.1.286       
2.3.1.306       2.3.1.-         2.3.2.2         2.3.2.10        
2.3.2.15        2.3.2.16        2.3.2.17        2.3.2.18        
2.3.2.35        2.3.2.-         3.4.11.1        3.4.11.2        
3.4.11.23       3.4.13.23       3.4.13.-        3.5.1.6         
3.5.1.12        3.5.1.17        3.5.1.20        3.5.1.21        
3.5.1.22        3.5.1.24        3.5.1.32        3.5.1.40        
3.5.1.46        3.5.1.48        3.5.1.51        3.5.1.53        
3.5.1.60        3.5.1.62        3.5.1.63        3.5.1.65        
3.5.1.71        3.5.1.74        3.5.1.78        3.5.1.85        
3.5.1.90        3.5.1.92        3.5.1.94        3.5.1.99        
3.5.1.119       3.5.1.-         4.3.2.6         4.3.2.8         
6.2.1.39        6.3.1.6         6.3.1.8         6.3.1.9         
6.3.1.10        6.3.1.11        6.3.1.19        6.3.2.1         
6.3.2.3         6.3.2.18        6.3.2.20        6.3.2.23        
6.3.2.36        6.3.2.37        6.3.2.44        6.3.2.46        
6.3.2.54        6.3.2.58        6.3.2.59        6.3.4.9         
6.3.4.10        6.3.4.11        6.3.4.15        6.3.4.24
 » show all
Pathway
rn00120  Primary bile acid biosynthesis
rn00220  Arginine biosynthesis
rn00240  Pyrimidine metabolism
rn00260  Glycine, serine and threonine metabolism
rn00300  Lysine biosynthesis
rn00310  Lysine degradation
rn00330  Arginine and proline metabolism
rn00332  Carbapenem biosynthesis
rn00340  Histidine metabolism
rn00380  Tryptophan metabolism
rn00410  beta-Alanine metabolism
rn00430  Taurine and hypotaurine metabolism
rn00440  Phosphonate and phosphinate metabolism
rn00460  Cyanoamino acid metabolism
rn00480  Glutathione metabolism
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn00550  Peptidoglycan biosynthesis
rn00680  Methane metabolism
rn00770  Pantothenate and CoA biosynthesis
rn00780  Biotin metabolism
rn00860  Porphyrin metabolism
rn00930  Caprolactam degradation
rn00983  Drug metabolism - other enzymes
rn00996  Biosynthesis of various alkaloids
rn00997  Biosynthesis of various other secondary metabolites
rn00998  Biosynthesis of various antibiotics
rn00999  Biosynthesis of various plant secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
RModule
RM024  Pyrimidine degradation
Orthology
K00611  ornithine carbamoyltransferase [EC:2.1.3.3]
K00628  glycine N-acyltransferase / glycine N-benzoyltransferase [EC:2.3.1.13 2.3.1.71]
K00657  diamine N-acetyltransferase [EC:2.3.1.57]
K00659  bile acid-CoA:amino acid N-acyltransferase [EC:2.3.1.65 3.1.2.2]
K00669  arylalkylamine N-acetyltransferase [EC:2.3.1.87]
K00681  gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
K01255  leucyl aminopeptidase [EC:3.4.11.1]
K01256  aminopeptidase N [EC:3.4.11.2]
K01270  dipeptidase D [EC:3.4.13.-]
K01431  beta-ureidopropionase [EC:3.5.1.6]
K01435  biotinidase [EC:3.5.1.12]
K01442  choloylglycine hydrolase [EC:3.5.1.24]
K01451  hippurate hydrolase [EC:3.5.1.32]
K01453  6-aminohexanoate-oligomer exohydrolase [EC:3.5.1.46]
K01460  glutathionylspermidine amidase/synthetase [EC:3.5.1.78 6.3.1.8]
K01833  trypanothione synthetase/amidase [EC:6.3.1.9 3.5.1.-]
K01917  glutathionylspermidine synthase [EC:6.3.1.8]
K01918  pantoate--beta-alanine ligase [EC:6.3.2.1]
K01920  glutathione synthase [EC:6.3.2.3]
K01942  biotin---protein ligase [EC:6.3.4.9 6.3.4.10 6.3.4.11 6.3.4.15]
K01947  biotin---[acetyl-CoA-carboxylase] ligase / type III pantothenate kinase [EC:6.3.4.15 2.7.1.33]
K02225  cobalamin biosynthesis protein CobC
K02227  adenosylcobinamide-phosphate synthase [EC:6.3.1.10]
K03524  BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
K05363  serine/alanine adding enzyme [EC:2.3.2.10]
K06016  beta-ureidopropionase / N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.6 3.5.1.87]
K06718  L-2,4-diaminobutyric acid acetyltransferase [EC:2.3.1.178]
K06914  tyramine---L-glutamate ligase [EC:6.3.4.24]
K07751  PepB aminopeptidase [EC:3.4.11.23]
K08069  pantetheine hydrolase [EC:3.5.1.92]
K08260  adenosylcobinamide hydrolase [EC:3.5.1.90]
K09065  N-acetylornithine carbamoyltransferase [EC:2.1.3.9]
K09470  gamma-glutamylputrescine synthase [EC:6.3.1.11]
K09473  gamma-glutamyl-gamma-aminobutyrate hydrolase [EC:3.5.1.94]
K09722  4-phosphopantoate---beta-alanine ligase [EC:6.3.2.36]
K09994  (aminoalkyl)phosphonate N-acetyltransferase [EC:2.3.1.280]
K11121  NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
K11140  aminopeptidase N [EC:3.4.11.2]
K11142  cytosol aminopeptidase [EC:3.4.11.1 3.4.11.5]
K11411  NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K11412  NAD-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]
K11413  NAD-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]
K11414  NAD-dependent protein deacetylase/lipoamidase sirtuin 4 [EC:2.3.1.286 2.3.1.313]
K11415  NAD-dependent protein deacetylase sirtuin 5 [EC:2.3.1.286]
K11416  NAD-dependent protein deacetylase sirtuin 6 [EC:2.3.1.286]
K11417  NAD-dependent protein deacetylase sirtuin 7 [EC:2.3.1.286]
K11693  peptidoglycan pentaglycine glycine transferase (the first glycine) [EC:2.3.2.16]
K11694  peptidoglycan pentaglycine glycine transferase (the second and third glycine) [EC:2.3.2.17]
K11695  peptidoglycan pentaglycine glycine transferase (the fourth and fifth glycine) [EC:2.3.2.18]
K12251  N-carbamoylputrescine amidase [EC:3.5.1.53]
K12410  NAD-dependent protein deacetylase/lipoamidase [EC:2.3.1.286 2.3.1.313]
K13043  N-succinyl-L-ornithine transcarbamylase [EC:2.1.3.11]
K13559  [BtrI acyl-carrier protein]--L-glutamate ligase [EC:6.2.1.39]
K13564  gamma-L-glutamyl-butirosin B gamma-L-glutamyl cyclotransferase [EC:4.3.2.6]
K13571  proteasome accessory factor A [EC:6.3.1.19]
K13799  pantoate ligase / CMP/dCMP kinase [EC:6.3.2.1 2.7.4.25]
K14329  agmatine coumaroyltransferase [EC:2.3.1.64 2.3.1.-]
K15428  Cys-Gly metallodipeptidase DUG1 [EC:3.4.13.-]
K15517  glycine N-phenylacetyltransferase [EC:2.3.1.192]
K16181  3-methylornithine--L-lysine ligase [EC:6.3.2.59]
K18566  N-acetyltransferase [EC:2.3.1.-]
K18572  putative pantetheine hydrolase [EC:3.5.1.-]
K18592  gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]
K18854  acetyl-CoA:lysine N6-acetyltransferase [EC:2.3.1.306]
K21456  glutathione synthase [EC:6.3.2.3]
K21935  beta-lysine N6-acetyltransferase [EC:2.3.1.264]
K22113  fumarate---(S)-2,3-diaminopropanoate ligase [EC:6.3.2.46]
K22450  aralkylamine N-acetyltransferase [EC:2.3.1.87]
K23372  L-2,3-diaminopropanoate---citrate ligase [EC:6.3.2.54]
K23446  D-ornithine---citrate ligase [EC:6.3.2.58]
K24277  capsaicin synthase [EC:2.3.2.35]

KEGG   RCLASS: RC00141
Entry
RC00141                     RClass                                 
Definition
C5a-C6a:N1b+*-*+O6a:C1c+O5a-C1c+O6a
Reactant pair
C00041_C20942    C00051_C00669    C00062_C21099
C00082_C02993    C00082_C07027    C00097_C01419
C00097_C19703    C00133_C00993    C00133_C04457
C00133_C19719    C00151_C16116    C00522_C00864
C00669_C04544    C00692_C01212    C01042_C12270
C01042_C20776    C01050_C01212    C01050_C04877
C01212_C22053    C01217_C18802    C01392_C05234
C02170_C20846    C02713_C02999    C02882_C05729
C03001_C04303    C03492_C18911    C04506_C20120
C04650_C06457    C04702_C05892    C04702_C06432
C04804_C04882    C04877_C04882    C05726_C05729
C05727_C20732    C05951_C05952    C12270_C20776
C12323_C20910    C17949_C17950    C19152_C19153
C19709_C19710    C19709_C19713    C20277_C20278
C20917_C20918    C20962_C20966    C20963_C20966
C20964_C20966    C20965_C20967    C21015_C21016
 » show all
Related class
Reaction
R00497 R00735 R00899 R01150 R02473 R02474 R02741 R02783
R03193 R04112 R04113 R04369 R04573 R04611 R04617 R04730
R04951 R05055 R05671 R07642 R07651 R08850 R08872 R09379
R09399 R09591 R09592 R09594 R09595 R09722 R09845 R10011
R10617 R10678 R10679 R10687 R10688 R10693 R10778 R10821
R10880 R10891 R10892 R10901 R10941 R10942 R10943 R10944
R10994 R11064 R11085 R11481 R12272 R12514
Enzyme
2.3.2.-         3.4.11.1        3.4.11.2        3.4.11.23       
3.4.13.22       3.4.13.23       3.4.13.-        3.4.15.6        
3.4.17.8        3.4.17.21       3.4.22.-        3.4.24.84       
3.4.-.-         3.5.1.22        3.5.1.28        3.5.1.72        
3.5.1.95        3.5.1.115       6.3.1.13        6.3.2.1         
6.3.2.3         6.3.2.4         6.3.2.8         6.3.2.9         
6.3.2.10        6.3.2.16        6.3.2.23        6.3.2.24        
6.3.2.25        6.3.2.29        6.3.2.31        6.3.2.33        
6.3.2.35        6.3.2.36        6.3.2.41        6.3.2.42        
6.3.2.44        6.3.2.45        6.3.2.47        6.3.2.48        
6.3.2.49        6.3.2.53        6.3.2.59        6.3.2.-
 » show all
Pathway
rn00240  Pyrimidine metabolism
rn00250  Alanine, aspartate and glutamate metabolism
rn00261  Monobactam biosynthesis
rn00270  Cysteine and methionine metabolism
rn00300  Lysine biosynthesis
rn00440  Phosphonate and phosphinate metabolism
rn00470  D-Amino acid metabolism
rn00480  Glutathione metabolism
rn00550  Peptidoglycan biosynthesis
rn00590  Arachidonic acid metabolism
rn00680  Methane metabolism
rn00770  Pantothenate and CoA biosynthesis
rn00790  Folate biosynthesis
rn00900  Terpenoid backbone biosynthesis
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Orthology
K01255  leucyl aminopeptidase [EC:3.4.11.1]
K01256  aminopeptidase N [EC:3.4.11.2]
K01270  dipeptidase D [EC:3.4.13.-]
K01446  peptidoglycan recognition protein
K01447  N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
K01448  N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
K01449  cell wall hydrolase
K01798  Alr-MurF fusion protein [EC:5.1.1.1 6.3.2.10]
K01918  pantoate--beta-alanine ligase [EC:6.3.2.1]
K01920  glutathione synthase [EC:6.3.2.3]
K01921  D-alanine-D-alanine ligase [EC:6.3.2.4]
K01924  UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]
K01925  UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
K01929  UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
K05375  MbtH protein
K06013  STE24 endopeptidase [EC:3.4.24.84]
K07751  PepB aminopeptidase [EC:3.4.11.23]
K08658  intramembrane prenyl-peptidase [EC:3.4.26.1]
K09722  4-phosphopantoate---beta-alanine ligase [EC:6.3.2.36]
K11140  aminopeptidase N [EC:3.4.11.2]
K11142  cytosol aminopeptidase [EC:3.4.11.1 3.4.11.5]
K12234  coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:6.3.2.31 6.3.2.34]
K12631  puromycin biosynthesis protein Pur6
K12911  phosphinothricin tripeptide synthetase PhsA
K12912  phosphinothricin tripeptide synthetase phsB [EC:6.2.1.67]
K12913  phosphinothricin tripeptide synthetase PhsC
K13037  L-alanine-L-anticapsin ligase [EC:6.3.2.49]
K13282  cyanophycinase [EC:3.4.15.6]
K13799  pantoate ligase / CMP/dCMP kinase [EC:6.3.2.1 2.7.4.25]
K14592  glutamate carboxypeptidase II (folate hydrolase 1) [EC:3.4.17.21]
K15428  Cys-Gly metallodipeptidase DUG1 [EC:3.4.13.-]
K15740  tetrahydromethanopterin:alpha-L-glutamate ligase [EC:6.3.2.33]
K15792  MurE/MurF fusion protein [EC:6.3.2.13 6.3.2.10]
K16181  3-methylornithine--L-lysine ligase [EC:6.3.2.59]
K18310  beta-citrylglutamate/N-acetylaspartylglutamate synthase [EC:6.3.1.17 6.3.2.41]
K18311  N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase [EC:6.3.2.41 6.3.2.42]
K19102  nocardicin nonribosomal peptide synthetase NocA
K19103  nocardicin nonribosomal peptide synthetase NocB
K19111  putative tabtoxin peptidase [EC:3.4.-.-]
K19112  L-Amino acid ligase [EC:6.3.2.-]
K19795  ureidomalonase [EC:3.5.1.95]
K21456  glutathione synthase [EC:6.3.2.3]
K22114  dapdiamide synthase [EC:6.3.2.47]
K23169  UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase [EC:6.3.2.53]
K24998  dehydro coenzyme F420 reductase / coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:1.3.8.17 6.3.2.31 6.3.2.34]

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