KEGG   REACTION: R00558
Entry
R00558                      Reaction                               
Name
L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)
Definition
L-Arginine + Oxygen + NADPH + H+ <=> N(omega)-Hydroxyarginine + NADP+ + H2O
Equation
C00062 + C00007 + C00005 + C00080 <=> C05933 + C00006 + C00001
Comment
the former part of multi-step reaction (see R00557, R00558+R00111)
subsequently R00111
NADH (see R10107)
Reaction class
RC00001  C00005_C00006
RC00330  C00062_C05933
Enzyme
1.14.13.39
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39
     R00558  L-Arginine + Oxygen + NADPH + H+ <=> N(omega)-Hydroxyarginine + NADP+ + H2O
Orthology
K13240  nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
K13242  nitric-oxide synthase, endothelial [EC:1.14.13.39]
K13427  nitric-oxide synthase, plant [EC:1.14.13.39]
Other DBs
RHEA: 24663
LinkDB

KEGG   RCLASS: RC00330
Entry
RC00330                     RClass                                 
Definition
N2a-N2b:*-O1b:C2c-C2c
Reactant pair
C00062_C05933
Related class
Reaction
R00558 R10107 R11033 R11712
Enzyme
1.14.13.39      1.14.14.47
Pathway
rn00330  Arginine and proline metabolism
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00491  nitric-oxide synthase, bacterial [EC:1.14.14.47]
K13240  nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
K13242  nitric-oxide synthase, endothelial [EC:1.14.13.39]
K13427  nitric-oxide synthase, plant [EC:1.14.13.39]
K19741  Nomega-hydroxy-L-arginine synthase [EC:1.14.-.-]

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