KEGG   REACTION: R00621
Entry
R00621                      Reaction                               
Definition
2-Oxoglutarate + Thiamin diphosphate <=> 3-Carboxy-1-hydroxypropyl-ThPP + CO2
Equation
Comment
2-oxoglutarate dehydrogenase complex: oxoglutarate dehydrogenase (see R01700)
TPP-dependent enzymatic reaction (see R00621+R03316)
subsequently R03316
Reaction class
RC00027  C00068_C05381
RC02743  C00026_C05381
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
LinkDB

KEGG   RCLASS: RC00027
Entry
RC00027                     RClass                                 
Definition
C8x-C8y:*-C1c:N5y+S2x-N5y+S2x
Reactant pair
Related class
Reaction
Enzyme
1.2.4.1         1.2.4.2         1.2.4.4         2.2.1.1         
2.2.1.3         2.2.1.6         4.1.1.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00166  2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4]
K01568  pyruvate decarboxylase [EC:4.1.1.1]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]

KEGG   RCLASS: RC02743
Entry
RC02743                     RClass                                 
Definition
C1c-C5a:C8y+*-*+C6a:C1b+O1a-C1b+O5a
Reactant pair
Related class
Reaction
Enzyme
1.2.4.2         1.2.4.4
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00166  2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]

DBGET integrated database retrieval system