KEGG   REACTION: R00742
Entry
R00742                      Reaction                               
Name
acetyl-CoA:carbon-dioxide ligase (ADP-forming)
Definition
ATP + Acetyl-CoA + HCO3- <=> ADP + Orthophosphate + Malonyl-CoA
Equation
C00002 + C00024 + C00288 <=> C00008 + C00009 + C00083
Comment
two-step reaction (see R04385+R04386)
Reaction class
RC00002  C00002_C00008
RC00040  C00024_C00083
RC00367  C00083_C00288
Enzyme
6.4.1.2
Pathway
rn00061  Fatty acid biosynthesis
rn00074  Mycolic acid biosynthesis
rn00254  Aflatoxin biosynthesis
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
Module
M00082  Fatty acid biosynthesis, initiation
M00375  Hydroxypropionate-hydroxybutylate cycle
M00376  3-Hydroxypropionate bi-cycle
M00885  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)
M00886  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.2
     R00742  ATP + Acetyl-CoA + HCO3- <=> ADP + Orthophosphate + Malonyl-CoA
Overall reaction [br08210.html]
 Carbon fixation
  R00742
Orthology
K01946  acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K01961  acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
K01962  acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
K01963  acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
K01964  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3]
K02160  acetyl-CoA carboxylase biotin carboxyl carrier protein
K11262  acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K11263  acetyl-CoA/propionyl-CoA/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
K15036  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K15037  biotin carboxyl carrier protein
K18472  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K18603  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3]
K18604  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K18605  biotin carboxyl carrier protein
K19312  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K22568  acetyl-CoA/propionyl-CoA carboxylase, PccX subunit [EC:6.4.1.2 6.4.1.3]
Other DBs
RHEA: 11311
LinkDB

KEGG   RCLASS: RC00040
Entry
RC00040                     RClass                                 
Definition
C1a-C1b:*-C6a:C5a-C5a
Reactant pair
C00022_C00036    C00024_C00083    C00164_C00207
C01209_C03939    C01875_C02367    C07113_C07114
C22571_C22572
Related class
Reaction
R00217 R00233 R00344 R00353 R00742 R00930 R01366 R03747
R04386 R05453 R05735 R08936 R09482 R12212 R13078
Enzyme
1.1.1.38        1.1.1.40        2.1.3.1         2.1.3.10        
2.1.3.15        4.1.1.4         4.1.1.9         4.1.1.56        
4.1.1.87        4.1.1.112       4.1.1.124       6.4.1.1         
6.4.1.2         6.4.1.6         6.4.1.8         7.2.4.2
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00061  Fatty acid biosynthesis
rn00074  Mycolic acid biosynthesis
rn00254  Aflatoxin biosynthesis
rn00410  beta-Alanine metabolism
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn00642  Ethylbenzene degradation
rn00650  Butanoate metabolism
rn00720  Other carbon fixation pathways
rn00946  Degradation of flavonoids
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
rn01220  Degradation of aromatic compounds
rn01230  Biosynthesis of amino acids
RModule
RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
Orthology
K01003  oxaloacetate decarboxylase [EC:4.1.1.112]
K01571  oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2]
K01573  oxaloacetate decarboxylase (Na+ extruding) subunit gamma
K01574  acetoacetate decarboxylase [EC:4.1.1.4]
K01578  malonyl-CoA decarboxylase [EC:4.1.1.9]
K01946  acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K01958  pyruvate carboxylase [EC:6.4.1.1]
K01959  pyruvate carboxylase subunit A [EC:6.4.1.1]
K01960  pyruvate carboxylase subunit B [EC:6.4.1.1]
K01961  acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
K01962  acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
K01963  acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
K01964  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3]
K02160  acetyl-CoA carboxylase biotin carboxyl carrier protein
K03416  methylmalonyl-CoA carboxyltransferase 5S subunit [EC:2.1.3.1]
K10701  acetophenone carboxylase [EC:6.4.1.8]
K10854  acetone carboxylase, alpha subunit [EC:6.4.1.6]
K10855  acetone carboxylase, beta subunit [EC:6.4.1.6]
K10856  acetone carboxylase, gamma subunit [EC:6.4.1.6]
K11262  acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K11263  acetyl-CoA/propionyl-CoA/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
K15036  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K15037  biotin carboxyl carrier protein
K17489  methylmalonyl-CoA carboxyltransferase 12S subunit [EC:2.1.3.1]
K17490  methylmalonyl-CoA carboxyltransferase 1.3S subunit [EC:2.1.3.1]
K18472  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K18603  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3]
K18604  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K18605  biotin carboxyl carrier protein
K19312  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K20509  carboxybiotin decarboxylase [EC:7.2.4.1]
K22568  acetyl-CoA/propionyl-CoA carboxylase, PccX subunit [EC:6.4.1.2 6.4.1.3]
K26185  naringenin degradation protein FdeI

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