KEGG   REACTION: R00888
Entry
R00888                      Reaction                               
Name
GDP-alpha-D-mannose 4,6-hydro-lyase (GDP-4-dehydro-alpha-D-rhamnose-forming);
GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)
Definition
GDP-mannose <=> GDP-4-dehydro-6-deoxy-D-mannose + H2O
Equation
C00096 <=> C01222 + C00001
Reaction class
RC00402  C00096_C01222
Enzyme
4.2.1.47
Pathway
rn00051  Fructose and mannose metabolism
rn00541  Biosynthesis of various nucleotide sugars
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.47
     R00888  GDP-mannose <=> GDP-4-dehydro-6-deoxy-D-mannose + H2O
Orthology
K01711  GDPmannose 4,6-dehydratase [EC:4.2.1.47]
Other DBs
RHEA: 23823
LinkDB

KEGG   RCLASS: RC00402
Entry
RC00402                     RClass                                 
Definition
C1a-C1b:*-O1a:C1y-C1y
C5x-C1y:*-*:C1y+C1y+O5x-C1y+C1y+O1a
Reactant pair
C00029_C04089    C00043_C04613    C00096_C01222
C00501_C01219    C00842_C11907    C21314_C21315
Related class
Reaction
R00293 R00888 R02426 R06513 R10266 R11430
Enzyme
4.2.1.45        4.2.1.46        4.2.1.47        4.2.1.76        
4.2.1.135
Pathway
rn00051  Fructose and mannose metabolism
rn00521  Streptomycin biosynthesis
rn00523  Polyketide sugar unit biosynthesis
rn00525  Acarbose and validamycin biosynthesis
rn00541  Biosynthesis of various nucleotide sugars
rn00552  Teichoic acid biosynthesis
rn01055  Biosynthesis of vancomycin group antibiotics
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Orthology
K01709  CDP-glucose 4,6-dehydratase [EC:4.2.1.45]
K01710  dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
K01711  GDPmannose 4,6-dehydratase [EC:4.2.1.47]
K12450  UDP-glucose 4,6-dehydratase [EC:4.2.1.76]
K15912  UDP-N-acetylglucosamine 4,6-dehydratase [EC:4.2.1.135]
K21211  NDP-hexose 4,6-dehydratase
K24300  UDP-N-acetylglucosamine 4,6-dehydratase [EC:4.2.1.135]
K24301  UDP-N-acetylglucosamine 4,6-dehydratase [EC:4.2.1.135]

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