KEGG   REACTION: R00937
Entry
R00937                      Reaction                               
Name
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Definition
Tetrahydrofolate + 2 NAD+ <=> Folate + 2 NADH + 2 H+
Equation
C00101 + 2 C00003 <=> C00504 + 2 C00004 + 2 C00080
Comment
two-step reaction (see R00936+R02235)
NADP+ (see R00940)
Reaction class
RC00001  C00003_C00004
RC00110  C00101_C00504
Enzyme
1.5.1.3
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3
     R00937  Tetrahydrofolate + 2 NAD+ <=> Folate + 2 NADH + 2 H+
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
LinkDB

KEGG   REACTION: R00940
Entry
R00940                      Reaction                               
Name
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Definition
Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+
Equation
C00101 + 2 C00006 <=> C00504 + 2 C00005 + 2 C00080
Comment
two-step reaction (see R00939+R02236)
NAD+ (see R00937)
Reaction class
RC00001  C00005_C00006
RC00110  C00101_C00504
Enzyme
1.5.1.3
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3
     R00940  Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
LinkDB

KEGG   RCLASS: RC00110
Entry
RC00110                     RClass                                 
Definition
C1x-C8x:*-*:C1y+N1x-C8y+N5x
C1y-C8y:*-*:C1b+C1x+N1x-C1b+C8x+N5x
N1x-N5x:*-*:C1x+C8y-C8x+C8y
N1x-N5x:*-*:C1y+C8y-C8y+C8y
Reactant pair
C00101_C00504
Related class
Reaction
R00937 R00940
Enzyme
1.5.1.3
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]

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