KEGG   REACTION: R01175
Entry
R01175                      Reaction                               
Name
butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Definition
Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA
Equation
C00136 + C00016 <=> C01352 + C00877
Reaction class
RC00076  C00136_C00877
RC00126  C00016_C01352
Enzyme
1.3.3.6         1.3.8.1         1.3.8.7         1.3.99.-
Pathway
rn00071  Fatty acid degradation
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
Module
M00087  beta-Oxidation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.3  With oxygen as acceptor
    1.3.3.6
     R01175  Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA
   1.3.8  With a flavin as acceptor
    1.3.8.1
     R01175  Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA
    1.3.8.7
     R01175  Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA
   1.3.99  With unknown physiological acceptors
    1.3.99.-
     R01175  Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.3.8.1
   R01178  Short-chain acyl-CoA <=> Electron-transferring flavoprotein
    R01175  Butanoyl-CoA <=> FAD
  1.3.8.7
   R00392  Acyl-CoA <=> Electron-transferring flavoprotein
    R01175  Butanoyl-CoA <=> FAD
Orthology
K00232  acyl-CoA oxidase [EC:1.3.3.6]
K00248  butyryl-CoA dehydrogenase [EC:1.3.8.1]
K00249  acyl-CoA dehydrogenase [EC:1.3.8.7]
K06445  acyl-CoA dehydrogenase [EC:1.3.99.-]
K09478  short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5]
Reference
1  [PMID:12057976]
  Authors
Campbell JW, Cronan JE Jr.
  Title
The enigmatic Escherichia coli fadE gene is yafH.
  Journal
J Bacteriol 184:3759-64 (2002)
DOI:10.1128/JB.184.13.3759-3764.2002
Other DBs
RHEA: 24007 30734
LinkDB

KEGG   RCLASS: RC00076
Entry
RC00076                     RClass                                 
Definition
C1b-C2b:*-*:C1a+C1b-C1a+C2b
C1b-C2b:*-*:C1b+C5a-C2b+C5a
Reactant pair
C00136_C00877    C04246_C05745
Related class
Reaction
R01171 R01175 R04429 R04430 R09738 R11675
Enzyme
1.3.1.9         1.3.1.10        1.3.1.39        1.3.1.44        
1.3.1.86        1.3.1.104       1.3.1.109       1.3.1.-         
1.3.3.6         1.3.8.1         1.3.8.7         1.3.99.-        
2.3.1.85        2.3.1.86        2.3.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn00071  Fatty acid degradation
rn00310  Lysine degradation
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
RModule
RM018  Beta oxidation in acyl-CoA degradation
RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
RM020  Fatty acid synthesis using acetyl-CoA (reversal of RM018)
RM021  Fatty acid synthesis using malonyl-CoA
Orthology
K00208  enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10]
K00209  enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase (NAD+) [EC:1.3.1.9 1.3.1.44]
K00232  acyl-CoA oxidase [EC:1.3.3.6]
K00248  butyryl-CoA dehydrogenase [EC:1.3.8.1]
K00249  acyl-CoA dehydrogenase [EC:1.3.8.7]
K00665  fatty acid synthase, animal type [EC:2.3.1.85]
K00668  fatty acid synthase subunit beta, fungi type [EC:2.3.1.86]
K02371  enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]
K06445  acyl-CoA dehydrogenase [EC:1.3.99.-]
K07512  mitochondrial enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase [EC:1.3.1.- 1.3.1.38]
K09478  short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5]
K10780  enoyl-[acyl-carrier protein] reductase III [EC:1.3.1.104]
K11533  fatty acid synthase, bacteria type [EC:2.3.1.-]
K17829  crotonyl-CoA reductase [EC:1.3.1.86]

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