KEGG   REACTION: R01248
Entry
R01248                      Reaction                               
Name
L-Proline:NAD+ 5-oxidoreductase
Definition
L-Proline + NAD+ <=> (S)-1-Pyrroline-5-carboxylate + NADH + H+
Equation
Comment
NADPH (see R01251)
Reaction class
RC00001  C00003_C00004
RC00083  C00148_C03912
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Orthology
K00286  pyrroline-5-carboxylate reductase [EC:1.5.1.2]
Other DBs
RHEA: 14108
LinkDB

KEGG   REACTION: R01251
Entry
R01251                      Reaction                               
Name
L-Proline:NADP+ 5-oxidoreductase
Definition
L-Proline + NADP+ <=> (S)-1-Pyrroline-5-carboxylate + NADPH + H+
Equation
Comment
NADH (see R01248)
Reaction class
RC00001  C00005_C00006
RC00083  C00148_C03912
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Module
M00015  Proline biosynthesis, glutamate => proline
Orthology
K00286  pyrroline-5-carboxylate reductase [EC:1.5.1.2]
Other DBs
RHEA: 14112
LinkDB

KEGG   RCLASS: RC00083
Entry
RC00083                     RClass                                 
Definition
C1x-C2x:*-*:C1x+N1x-C1x+N2x
N1x-N2x:*-*:C1x+C1y-C2x+C1y
Reactant pair
Related class
Reaction
Enzyme
1.5.1.2         1.5.3.7         1.5.5.2         1.5.99.3        
1.5.-.-
Pathway
rn00310  Lysine degradation
rn00330  Arginine and proline metabolism
rn00332  Carbapenem biosynthesis
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Orthology
K00286  pyrroline-5-carboxylate reductase [EC:1.5.1.2]
K00306  sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.1 1.5.3.7]
K00318  proline dehydrogenase [EC:1.5.5.2]
K13821  RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
K18318  carbapenem biosynthesis protein, putative proline dehydrogenase [EC:1.5.-.-]
K18319  carbapenem biosynthesis protein CpmE

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