KEGG   REACTION: R01252
Entry
R01252                      Reaction                               
Name
L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
Definition
L-Proline + 2-Oxoglutarate + Oxygen <=> Hydroxyproline + Succinate + CO2
Equation
C00148 + C00026 + C00007 <=> C01157 + C00042 + C00011
Reaction class
RC00478  C00148_C01157
Enzyme
1.14.11.2       1.14.11.57
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.2
     R01252  L-Proline + 2-Oxoglutarate + Oxygen <=> Hydroxyproline + Succinate + CO2
    1.14.11.57
     R01252  L-Proline + 2-Oxoglutarate + Oxygen <=> Hydroxyproline + Succinate + CO2
Orthology
K00472  prolyl 4-hydroxylase [EC:1.14.11.2]
Other DBs
RHEA: 51511
LinkDB

KEGG   RCLASS: RC00478
Entry
RC00478                     RClass                                 
Definition
C1x-C1y:*-O1a:C1x+C1x-C1x+C1x
Reactant pair
C00148_C01015    C00148_C01157    C00854_C11249
C01078_C04398    C02035_C06096    C02094_C08591
C02621_C10772    C03972_C20258    C04404_C09822
C05433_C08590    C06098_C08591    C08592_C15965
C08601_C15981    C09092_C21819    C11863_C11865
C15935_C15937    C15940_C15941    C15966_C15968
C15982_C15983    C18226_C21827    C20145_C20146
Related class
Reaction
R01252 R03219 R03809 R04198 R04199 R06337 R06945 R07530
R07554 R07556 R07558 R07559 R07561 R07570 R07579 R07851
R09050 R09861 R11594 R11974 R11982 R13327
Enzyme
1.14.11.2       1.14.11.13      1.14.11.56      1.14.11.57      
1.14.13.-       1.14.14.62      1.14.14.69      1.14.14.76      
1.14.15.3       1.14.15.24      1.14.15.40      1.14.-.-        
1.17.1.8
Pathway
rn00261  Monobactam biosynthesis
rn00300  Lysine biosynthesis
rn00330  Arginine and proline metabolism
rn00362  Benzoate degradation
rn00904  Diterpenoid biosynthesis
rn00906  Carotenoid biosynthesis
rn00930  Caprolactam degradation
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01230  Biosynthesis of amino acids
Orthology
K00215  4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]
K00472  prolyl 4-hydroxylase [EC:1.14.11.2]
K00496  alkane 1-monooxygenase [EC:1.14.15.3]
K00529  3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]
K02294  beta-carotene hydroxylase [EC:1.14.13.-]
K04125  gibberellin 2beta-dioxygenase [EC:1.14.11.13]
K04755  ferredoxin, 2Fe-2S
K15746  beta-carotene 3-hydroxylase [EC:1.14.15.24]
K15747  beta-ring hydroxylase [EC:1.14.-.-]
K16083  ent-isokaurene hydroxylase [EC:1.14.14.76]
K22492  beta-carotene 3-hydroxylase [EC:1.14.15.24]
K22634  salviol synthase [EC:1.14.14.62]
K23037  beta-carotene 4-ketolase/3-hydroxylase [EC:1.14.99.63 1.14.15.24 1.14.99.-]
K27672  cyclohexane-1-carboxylate 4-trans-hydroxylase [EC:1.14.15.40]

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