REACTION: R01273
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Entry
R01273 Reaction
Name
N-ribosylnicotinamide ribohydrolase
Definition
Nicotinamide-beta-riboside + H2O <=> Nicotinamide + D-Ribose
Equation
C03150
+
C00001
<=>
C00153
+
C00121
Reaction class
RC00033
C00153_C03150
RC00485
C00121_C03150
Enzyme
3.2.2.3
Pathway
rn00760
Nicotinate and nicotinamide metabolism
rn01100
Metabolic pathways
Brite
Enzymatic reactions [BR:
br08201
]
3. Hydrolase reactions
3.2 Glycosylases
3.2.2 Hydrolysing N-glycosyl compounds
3.2.2.3
R01273 Nicotinamide-beta-riboside + H2O <=> Nicotinamide + D-Ribose
BRITE hierarchy
Orthology
K01240
uridine nucleosidase [EC:
3.2.2.3
]
Reference
1 [PMID:
19001417
]
Authors
Belenky P, Christensen KC, Gazzaniga F, Pletnev AA, Brenner C.
Title
Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism.
Journal
J Biol Chem 284:158-64 (2009)
DOI:
10.1074/jbc.M807976200
Other DBs
RHEA:
30746
LinkDB
All DBs
RCLASS: RC00033
Help
Entry
RC00033 RClass
Definition
N5x-N5y:*-C1y:C8x+C8x-C8x+C8x
Reactant pair
C00003_C00153
C00006_C00153
C00153_C00455
C00153_C03150
C00253_C01185
C00253_C03003
C00253_C05841
C00253_C13051
C00396_C03169
C00396_C03536
C19574_C19606
Related class
DB search
Reaction
R00102
R00119
R00555
R01270
R01271
R01273
R01722
R01724
R02171
R02172
R02294
R02295
R02298
R03447
R04074
R04148
R04176
R09427
R10046
R10608
R10629
R10631
R10632
R10633
R10634
R10685
R12026
Enzyme
2.3.1.286
2.4.1.17
2.4.1.196
2.4.2.1
2.4.2.2
2.4.2.12
2.4.2.21
2.4.2.30
2.4.2.31
2.4.2.36
2.4.2.37
2.4.2.55
2.4.2.59
2.4.2.60
2.4.99.20
3.2.2.3
3.2.2.5
3.2.2.6
3.2.2.8
3.2.2.10
3.2.2.14
3.5.1.-
6.3.4.21
Pathway
rn00760
Nicotinate and nicotinamide metabolism
rn01100
Metabolic pathways
rn01240
Biosynthesis of cofactors
Orthology
K00699
glucuronosyltransferase [EC:
2.4.1.17
]
K00763
nicotinate phosphoribosyltransferase [EC:
6.3.4.21
]
K00768
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [EC:
2.4.2.21
]
K01240
uridine nucleosidase [EC:
3.2.2.3
]
K01242
ADP-ribosyl cyclase 1 [EC:
3.2.2.6
2.4.99.20
]
K03146
cysteine-dependent adenosine diphosphate thiazole synthase [EC:
2.4.2.60
]
K03462
nicotinamide phosphoribosyltransferase [EC:
2.4.2.12
]
K03783
purine-nucleoside phosphorylase [EC:
2.4.2.1
]
K03784
purine-nucleoside phosphorylase [EC:
2.4.2.1
]
K11121
NAD-dependent protein deacetylase SIR2 [EC:
2.3.1.286
]
K11411
NAD-dependent protein deacetylase sirtuin 1 [EC:
2.3.1.286
]
K11412
NAD-dependent protein deacetylase sirtuin 2 [EC:
2.3.1.286
]
K11413
NAD-dependent protein deacetylase sirtuin 3 [EC:
2.3.1.286
]
K11414
NAD-dependent protein deacetylase/lipoamidase sirtuin 4 [EC:
2.3.1.286
2.3.1.313
]
K11415
NAD-dependent protein deacetylase sirtuin 5 [EC:
2.3.1.286
]
K11416
NAD-dependent protein deacetylase sirtuin 6 [EC:
2.3.1.286
]
K11417
NAD-dependent protein deacetylase sirtuin 7 [EC:
2.3.1.286
]
K12410
NAD-dependent protein deacetylase/lipoamidase [EC:
2.3.1.286
2.3.1.313
]
K18152
ADP-ribosyl cyclase 2 [EC:
3.2.2.6
2.4.99.20
]
K18153
NAD+ glycohydrolase [EC:
3.2.2.5
]
K19980
ADP-ribosyltransferase 2 / NAD+ glycohydrolase [EC:
2.4.2.31
3.2.2.5
]
K22699
sulfide-dependent adenosine diphosphate thiazole synthase [EC:
2.4.2.59
]
K27536
NAD(+) hydrolase SARM1 [EC:
3.2.2.6
]
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