KEGG   REACTION: R01290
Entry
R01290                      Reaction                               
Name
L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
Definition
L-Serine + L-Homocysteine <=> L-Cystathionine + H2O
Equation
C00065 + C00155 <=> C02291 + C00001
Comment
multi-step reaction (hydro-lyase, L-homocysteine-lyase)
Reaction class
RC00069  C00155_C02291
RC00489  C00065_C02291
Enzyme
4.2.1.22
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Module
M00035  Methionine degradation
M00338  Cysteine biosynthesis, homocysteine + serine => cysteine
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.22
     R01290  L-Serine + L-Homocysteine <=> L-Cystathionine + H2O
Orthology
K01697  cystathionine beta-synthase [EC:4.2.1.22]
K10150  cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22]
Other DBs
RHEA: 10115
LinkDB

KEGG   RCLASS: RC00069
Entry
RC00069                     RClass                                 
Definition
S1a-S2a:*-C1b:C1b-C1b
Reactant pair
C00021_C00155    C00051_C14180    C00051_C14865
C00051_C14871    C00097_C00542    C00097_C02291
C00097_C06751    C00097_C19691    C00155_C00542
C00155_C02291    C00155_C03539    C01242_C02972
C02086_C03727    C03576_C11496    C03576_C11497
C03576_C11498    C06717_C18235    C20119_C20120
Related class
Reaction
R00192 R01001 R01286 R01289 R01290 R01291 R02508 R03217
R03260 R04003 R04125 R05713 R05761 R05762 R06982 R07092
R07116 R07360 R08632 R09562 R09844 R10301 R10302 R10305
Enzyme
1.1.1.306       1.8.1.5         1.8.3.5         1.8.3.6         
2.1.2.10        2.5.1.18        2.5.1.48        2.5.1.58        
2.5.1.134       3.13.2.1        4.2.1.22        4.4.1.1         
4.4.1.13        4.4.1.21        4.4.1.22        4.4.1.23        
4.5.1.5
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn00670  One carbon pool by folate
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Orthology
K00153  S-(hydroxymethyl)mycothiol dehydrogenase [EC:1.1.1.306]
K00605  glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]
K00799  glutathione S-transferase [EC:2.5.1.18]
K00816  kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64]
K01251  adenosylhomocysteinase [EC:3.13.2.1]
K01697  cystathionine beta-synthase [EC:4.2.1.22]
K01739  cystathionine gamma-synthase [EC:2.5.1.48]
K01758  cystathionine gamma-lyase [EC:4.4.1.1]
K01760  cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
K03396  S-(hydroxymethyl)glutathione synthase [EC:4.4.1.22]
K04097  prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
K05906  prenylcysteine oxidase / farnesylcysteine lyase [EC:1.8.3.5 1.8.3.6]
K05954  protein farnesyltransferase subunit beta [EC:2.5.1.58]
K05955  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [EC:2.5.1.58 2.5.1.59]
K07173  S-ribosylhomocysteine lyase [EC:4.4.1.21]
K10150  cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22]
K13299  glutathione S-transferase kappa 1 [EC:2.5.1.18]
K14155  cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
K17216  cystathionine beta-synthase (O-acetyl-L-serine) [EC:2.5.1.134]
K17217  cystathionine gamma-lyase / homocysteine desulfhydrase [EC:4.4.1.1 4.4.1.2]
K23790  glutathione S-transferase P [EC:2.5.1.18]

KEGG   RCLASS: RC00489
Entry
RC00489                     RClass                                 
Definition
C1b-C1b:O1a+*-*+S2a:C1c-C1c
Reactant pair
C00065_C00542    C00065_C02291
Related class
Reaction
R01289 R01290
Enzyme
4.2.1.22
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Orthology
K01697  cystathionine beta-synthase [EC:4.2.1.22]
K10150  cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22]

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