KEGG   REACTION: R01360
Entry
R01360                      Reaction                               
Name
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)
Definition
(S)-3-Hydroxy-3-methylglutaryl-CoA <=> Acetyl-CoA + Acetoacetate
Equation
C00356 <=> C00024 + C00164
Reaction class
RC00502  C00024_C00356
RC00503  C00164_C00356
Enzyme
4.1.3.4
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
Module
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
M00088  Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.4
     R01360  (S)-3-Hydroxy-3-methylglutaryl-CoA <=> Acetyl-CoA + Acetoacetate
Orthology
K01640  hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]
Other DBs
RHEA: 24407
LinkDB

KEGG   RCLASS: RC00502
Entry
RC00502                     RClass                                 
Definition
C1a-C1b:*-C1d:C5a-C5a
Reactant pair
C00022_C04115    C00022_C06033    C00024_C00356
C00024_C00566    C00024_C01011    C00024_C20746
Related class
Reaction
R00008 R00237 R00350 R00354 R01360 R10674
Enzyme
4.1.3.4         4.1.3.17        4.1.3.25        4.1.3.34        
4.1.3.46
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00362  Benzoate degradation
rn00650  Butanoate metabolism
rn00660  C5-Branched dibasic acid metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Orthology
K01640  hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]
K08691  malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25]
K10218  4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17]
K15234  citryl-CoA lyase [EC:4.1.3.34]
K18292  (S)-citramalyl-CoA lyase [EC:4.1.3.25]
K18314  (R)-citramalyl-CoA lyase [EC:4.1.3.46]

KEGG   RCLASS: RC00503
Entry
RC00503                     RClass                                 
Definition
C1d-C5a:C1b-*:C1a+C1b+O1a-C1a+C1b+O5a
Reactant pair
C00164_C00356    C00332_C00356
Related class
Reaction
R01360 R01978
Enzyme
2.3.3.10        4.1.3.4
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00650  Butanoate metabolism
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K01640  hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]
K01641  hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]

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