KEGG   REACTION: R01454
Entry
R01454                      Reaction                               
Name
Cholesterol:oxygen oxidoreductase (side-chain-cleaving)
Definition
Cholesterol + Oxygen + 2 H+ + 2 Reduced adrenal ferredoxin <=> 20alpha-Hydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Equation
C00187 + C00007 + 2 C00080 + 2 C00662 <=> C05500 + C00001 + 2 C00667
Comment
first step of R02724 (R01454+R04854+R03933)
Reaction class
RC00521  C00187_C05500
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
LinkDB

KEGG   REACTION: R04854
Entry
R04854                      Reaction                               
Name
20alpha-Hydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)
Definition
20alpha-Hydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 20alpha,22beta-Dihydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Equation
C05500 + C00007 + 2 C00662 + 2 C00080 <=> C05501 + C00001 + 2 C00667
Comment
second step of R02724 (R01454+R04854+R03933)
Reaction class
RC01223  C05500_C05501
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
LinkDB

KEGG   REACTION: R03933
Entry
R03933                      Reaction                               
Name
20alpha,22beta-Dihydroxycholesterol,ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
Definition
20alpha,22beta-Dihydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 4-Methylpentanal + Pregnenolone + 2 H2O + 2 Oxidized adrenal ferredoxin
Equation
C05501 + C00007 + 2 C00662 + 2 C00080 <=> C02373 + C01953 + 2 C00001 + 2 C00667
Comment
third step of R02724 (R01454+R04854+R03933 or R02723+R04855+R03933)
Reaction class
RC01029  C01953_C05501
RC01030  C02373_C05501
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Other DBs
RHEA: 34346
LinkDB

KEGG   REACTION: R02723
Entry
R02723                      Reaction                               
Definition
Cholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 22(R)-Hydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Equation
C00187 + C00007 + 2 C00662 + 2 C00080 <=> C05502 + C00001 + 2 C00667
Comment
first step of R02724 (R02723+R04855+R03933)
Reaction class
RC00773  C00187_C05502
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Other DBs
RHEA: 34338
LinkDB

KEGG   REACTION: R04855
Entry
R04855                      Reaction                               
Name
22beta-Hydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)
Definition
22(R)-Hydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 20alpha,22beta-Dihydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Equation
C05502 + C00007 + 2 C00662 + 2 C00080 <=> C05501 + C00001 + 2 C00667
Comment
second step of R02724 (R02723+R04855+R03933)
Reaction class
RC00706  C05501_C05502
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Other DBs
RHEA: 34342
LinkDB

KEGG   REACTION: R03933
Entry
R03933                      Reaction                               
Name
20alpha,22beta-Dihydroxycholesterol,ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
Definition
20alpha,22beta-Dihydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 4-Methylpentanal + Pregnenolone + 2 H2O + 2 Oxidized adrenal ferredoxin
Equation
C05501 + C00007 + 2 C00662 + 2 C00080 <=> C02373 + C01953 + 2 C00001 + 2 C00667
Comment
third step of R02724 (R01454+R04854+R03933 or R02723+R04855+R03933)
Reaction class
RC01029  C01953_C05501
RC01030  C02373_C05501
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Other DBs
RHEA: 34346
LinkDB

DBGET integrated database retrieval system