KEGG   REACTION: R01702
Entry
R01702                      Reaction                               
Name
4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
Definition
4-Methyl-2-oxopentanoate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + CO2
Equation
C00233 + C15972 <=> C15975 + C00011
Comment
3-methyl-2-oxobutanoate dehydrogenase complexes:3-methyl-2-oxobutanoate dehydrogenase
a part of multi-step reaction (see R01702+R04097+R07618, possibly identical to R01651)
subsequently R04097
TPP-dependent enzyme (see R07601+R07602)
Reaction class
RC00627  C15972_C15975
RC02833  C00233_C15975
Enzyme
1.2.4.4
Pathway
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.4
     R01702  4-Methyl-2-oxopentanoate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + CO2
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
LinkDB

KEGG   REACTION: R04097
Entry
R04097                      Reaction                               
Name
3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase
Definition
3-Methylbutanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
Equation
C02939 + C15973 <=> C00010 + C15975
Comment
3-methyl-2-oxobutanoate dehydrogenase complexes:3-methyl-2-oxobutanoate dehydrogenase
a part of multi-step reaction (see R01702+R04097+R07618, possibly identical to R01651)
following after R01702
Reaction class
RC00004  C00010_C02939  C15973_C15975
RC02727  C02939_C15975
Enzyme
2.3.1.168
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
Module
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.168
     R04097  3-Methylbutanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
Orthology
K09699  2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168]
LinkDB

KEGG   REACTION: R07618
Entry
R07618                      Reaction                               
Name
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Definition
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
Equation
C15973 + C00003 <=> C15972 + C00004 + C00080
Comment
Oxo-acid dehydrogenase complexes, dihydrolipoyl dehydrogenase
Reaction class
RC00001  C00003_C00004
RC00583  C15972_C15973
Enzyme
1.8.1.4
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.8  Acting on a sulfur group of donors
   1.8.1  With NAD+ or NADP+ as acceptor
    1.8.1.4
     R07618  Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.8.1.4
   R08550  [Protein]-N6-[(R)-dihydrolipoyl]-L-lysine <=> Protein N6-(lipoyl)lysine
    R07618  Enzyme N6-(dihydrolipoyl)lysine <=> Enzyme N6-(lipoyl)lysine
Orthology
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
Other DBs
RHEA: 15048
LinkDB

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