KEGG   REACTION: R01773
Entry
R01773                      Reaction                               
Name
L-Homoserine:NAD+ oxidoreductase
Definition
L-Homoserine + NAD+ <=> L-Aspartate 4-semialdehyde + NADH + H+
Equation
C00263 + C00003 <=> C00441 + C00004 + C00080
Comment
NADP+ (see R01775)
Reaction class
RC00001  C00003_C00004
RC00087  C00263_C00441
Enzyme
1.1.1.3
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01230  Biosynthesis of amino acids
Module
M00017  Methionine biosynthesis, aspartate => homoserine => methionine
M00018  Threonine biosynthesis, aspartate => homoserine => threonine
Orthology
K00003  homoserine dehydrogenase [EC:1.1.1.3]
K12524  bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
K12525  bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:2.7.2.4 1.1.1.3]
Other DBs
RHEA: 15760
LinkDB

KEGG   REACTION: R01775
Entry
R01775                      Reaction                               
Name
L-homoserine:NADP+ oxidoreductase
Definition
L-Homoserine + NADP+ <=> L-Aspartate 4-semialdehyde + NADPH + H+
Equation
C00263 + C00006 <=> C00441 + C00005 + C00080
Comment
NAD+ (see R01773)
Reaction class
RC00001  C00005_C00006
RC00087  C00263_C00441
Enzyme
1.1.1.3
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01230  Biosynthesis of amino acids
Module
M00017  Methionine biosynthesis, aspartate => homoserine => methionine
M00018  Threonine biosynthesis, aspartate => homoserine => threonine
Orthology
K00003  homoserine dehydrogenase [EC:1.1.1.3]
K12524  bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
K12525  bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:2.7.2.4 1.1.1.3]
Other DBs
RHEA: 15764
LinkDB

KEGG   RCLASS: RC00087
Entry
RC00087                     RClass                                 
Definition
C1b-C4a:*-*:C1b+O1a-C1b+O4a
Reactant pair
C00114_C00576    C00222_C01013    C00232_C00989
C00263_C00441    C00266_C01380    C00378_C05856
C00479_C05979    C00517_C00823    C00593_C05123
C00601_C05853    C00637_C00955    C00756_C01545
C00891_C00892    C00969_C02457    C01412_C06142
C02217_C02774    C02804_C03273    C03167_C06451
C03765_C06044    C05668_C05989    C06102_C06103
C06145_C06146    C06753_C06754    C07328_C07329
C07645_C16551    C08492_C16310    C09848_C09849
C11384_C11386    C14871_C14875    C16556_C16558
C18218_C19614    C19616_C19617    C19623_C19624
C21696_C21699
 » show all
Related class
Reaction
R00033 R01022 R01025 R01608 R01644 R01773 R01775 R01781
R02377 R02462 R02600 R02611 R02679 R02680 R02878 R03043
R03044 R03119 R03544 R03545 R03886 R04304 R04919 R05121
R05231 R05283 R05285 R05685 R05686 R06981 R07120 R07409
R08084 R08085 R08281 R08290 R08557 R08558 R08861 R09128
R09281 R09289 R09448 R09455 R09456 R09478 R10125 R10126
R10783 R10981 R11343 R11344 R11808
Enzyme
1.1.1.1         1.1.1.2         1.1.1.3         1.1.1.59        
1.1.1.61        1.1.1.66        1.1.1.73        1.1.1.77        
1.1.1.90        1.1.1.150       1.1.1.151       1.1.1.164       
1.1.1.183       1.1.1.190       1.1.1.191       1.1.1.192       
1.1.1.202       1.1.1.258       1.1.1.265       1.1.1.298       
1.1.1.309       1.1.1.313       1.1.1.-         1.1.2.7         
1.1.2.8         1.1.2.9         1.1.2.-         1.1.3.17        
1.1.3.23        1.1.5.11        1.1.99.1        1.1.-.-         
1.14.14.49      1.14.15.7
Pathway
rn00071  Fatty acid degradation
rn00073  Cutin, suberine and wax biosynthesis
rn00240  Pyrimidine metabolism
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn00300  Lysine biosynthesis
rn00350  Tyrosine metabolism
rn00360  Phenylalanine metabolism
rn00380  Tryptophan metabolism
rn00410  beta-Alanine metabolism
rn00430  Taurine and hypotaurine metabolism
rn00440  Phosphonate and phosphinate metabolism
rn00561  Glycerolipid metabolism
rn00592  alpha-Linolenic acid metabolism
rn00625  Chloroalkane and chloroalkene degradation
rn00630  Glyoxylate and dicarboxylate metabolism
rn00640  Propanoate metabolism
rn00650  Butanoate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn00730  Thiamine metabolism
rn00930  Caprolactam degradation
rn00980  Metabolism of xenobiotics by cytochrome P450
rn00982  Drug metabolism - cytochrome P450
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01220  Degradation of aromatic compounds
rn01230  Biosynthesis of amino acids
RModule
RM017  Ring cleavage via Baeyer-Villiger oxidation
RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
Orthology
K00001  alcohol dehydrogenase [EC:1.1.1.1]
K00002  alcohol dehydrogenase (NADP+) [EC:1.1.1.2]
K00003  homoserine dehydrogenase [EC:1.1.1.3]
K00043  4-hydroxybutyrate dehydrogenase [EC:1.1.1.61]
K00048  lactaldehyde reductase [EC:1.1.1.77]
K00055  aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00086  1,3-propanediol dehydrogenase [EC:1.1.1.202]
K00100  butanol dehydrogenase [EC:1.1.1.-]
K00108  choline dehydrogenase [EC:1.1.99.1]
K00114  alcohol dehydrogenase (cytochrome c) [EC:1.1.2.8]
K00121  S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
K00499  choline monooxygenase [EC:1.14.15.7]
K08318  4-hydroxybutyrate dehydrogenase / sulfolactaldehyde 3-reductase [EC:1.1.1.61 1.1.1.373]
K09019  3-hydroxypropanoate dehydrogenase [EC:1.1.1.-]
K11440  choline dehydrogenase [EC:1.1.1.1]
K12524  bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
K12525  bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:2.7.2.4 1.1.1.3]
K12901  phosphonoacetaldehyde reductase
K12904  phosphonoacetaldehyde reductase [EC:1.1.1.309]
K13774  citronellol/citronellal dehydrogenase
K13775  citronellol/citronellal dehydrogenase
K13921  1-propanol dehydrogenase
K13951  alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13952  alcohol dehydrogenase 6 [EC:1.1.1.1]
K13953  alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K13980  alcohol dehydrogenase 4 [EC:1.1.1.1]
K14028  methanol dehydrogenase (cytochrome c) subunit 1 [EC:1.1.2.7]
K14029  methanol dehydrogenase (cytochrome c) subunit 2 [EC:1.1.2.7]
K14465  succinate semialdehyde reductase (NADPH) [EC:1.1.1.-]
K14468  malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+) [EC:1.2.1.75 1.1.1.298]
K15039  3-hydroxypropionate dehydrogenase (NADP+) [EC:1.1.1.298]
K15373  sulfoacetaldehyde reductase [EC:1.1.1.313]
K15403  fatty acid omega-hydroxy dehydrogenase [EC:1.1.-.-]
K16066  3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-]
K17755  choline oxidase [EC:1.1.3.17]
K18120  4-hydroxybutyrate dehydrogenase [EC:1.1.1.61]
K18121  glyoxylate/succinic semialdehyde reductase [EC:1.1.1.79 1.1.1.-]
K18602  malonic semialdehyde reductase [EC:1.1.1.-]
K18857  alcohol dehydrogenase class-P [EC:1.1.1.1]
K19961  6-hydroxyhexanoate dehydrogenase [EC:1.1.1.258]
K23146  3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase [EC:1.1.1.31 1.1.1.59]

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