REACTION: R01840
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Entry
R01840 Reaction
Name
androstenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (19-hydroxylating)
Definition
Androstenedione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Hydroxyandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00280
+
C03024
+
C00007
<=>
C05290
+
C03161
+
C00001
Comment
aromatase, ARO
three successive reactions (
R01840+R04759+R02351
)
subsequently
R04759
Reaction class
RC00257
C00280_C05290
Enzyme
1.14.14.14
Pathway
rn00140
Steroid hormone biosynthesis
rn01100
Metabolic pathways
Module
M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Orthology
K07434
aromatase [EC:
1.14.14.14
]
Other DBs
RHEA:
38202
LinkDB
All DBs
REACTION: R04759
Help
Entry
R04759 Reaction
Name
19-hydroxyandrostenedione,NADPH---hemoprotein reductase:oxygen 19-oxidoreductase
Definition
19-Hydroxyandrost-4-ene-3,17-dione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Oxoandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C05290
+
C03024
+
C00007
<=>
C05297
+
C03161
+ 2
C00001
Comment
aromatase, ARO
following after
R01840
subsequently
R02351
Reaction class
RC00893
C05290_C05297
Enzyme
1.14.14.14
Pathway
rn00140
Steroid hormone biosynthesis
rn01100
Metabolic pathways
Module
M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Orthology
K07434
aromatase [EC:
1.14.14.14
]
Other DBs
RHEA:
38206
LinkDB
All DBs
REACTION: R02351
Help
Entry
R02351 Reaction
Name
19-oxoandrostenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (aromatizing, formate-forming)
Definition
19-Oxoandrost-4-ene-3,17-dione + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Estrone + Formate + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C05297
+
C00007
+
C03024
<=>
C00468
+
C00058
+
C03161
+
C00001
Comment
aromatase, ARO
following after
R04759
Reaction class
RC02649
C00468_C05297
Enzyme
1.14.14.14
Pathway
rn00140
Steroid hormone biosynthesis
rn01100
Metabolic pathways
Module
M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Orthology
K07434
aromatase [EC:
1.14.14.14
]
Other DBs
RHEA:
38210
LinkDB
All DBs
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