KEGG   REACTION: R01840
Entry
R01840                      Reaction                               
Name
androstenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (19-hydroxylating)
Definition
Androstenedione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Hydroxyandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Comment
aromatase, ARO
three successive reactions (R01840+R04759+R02351)
subsequently R04759
Reaction class
RC00257  C00280_C05290
Enzyme
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38202
LinkDB

KEGG   REACTION: R04759
Entry
R04759                      Reaction                               
Name
19-hydroxyandrostenedione,NADPH---hemoprotein reductase:oxygen 19-oxidoreductase
Definition
19-Hydroxyandrost-4-ene-3,17-dione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Oxoandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
Comment
aromatase, ARO
following after R01840
subsequently R02351
Reaction class
RC00893  C05290_C05297
Enzyme
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38206
LinkDB

KEGG   REACTION: R02351
Entry
R02351                      Reaction                               
Name
19-oxoandrostenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (aromatizing, formate-forming)
Definition
19-Oxoandrost-4-ene-3,17-dione + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Estrone + Formate + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Comment
aromatase, ARO
following after R04759
Reaction class
RC02649  C00468_C05297
Enzyme
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38210
LinkDB

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