KEGG   REACTION: R01899
Entry
R01899                      Reaction                               
Name
isocitrate:NADP+ oxidoreductase
Definition
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
Equation
C00311 + C00006 <=> C05379 + C00005 + C00080
Comment
the first step of two-step reaction (see R00267, R01899+R00268)
subsequently R00268
Reaction class
RC00001  C00005_C00006
RC00084  C00311_C05379
Enzyme
1.1.1.42
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00740  Methylaspartate cycle
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.42
     R01899  Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 25591
LinkDB

KEGG   REACTION: R00268
Entry
R00268                      Reaction                               
Name
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Definition
Oxalosuccinate <=> 2-Oxoglutarate + CO2
Equation
C05379 <=> C00026 + C00011
Comment
the second step of two-step reaction (see R00267, R01899+R00268)
following after R01899
Reaction class
RC00626  C00026_C05379
Enzyme
1.1.1.42
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00740  Methylaspartate cycle
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.42
     R00268  Oxalosuccinate <=> 2-Oxoglutarate + CO2
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 19384
LinkDB

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