KEGG   REACTION: R01977
Entry
R01977                      Reaction                               
Name
(R)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase
Definition
(R)-3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+
Equation
C03561 + C00006 <=> C00332 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00117  C00332_C03561
Enzyme
1.1.1.36
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00373  Ethylmalonyl pathway
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.36
     R01977  (R)-3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.36
   R01779  (3R)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R01977  (R)-3-Hydroxybutanoyl-CoA <=> Acetoacetyl-CoA
Orthology
K00023  acetoacetyl-CoA reductase [EC:1.1.1.36]
Other DBs
RHEA: 45799
LinkDB

KEGG   RCLASS: RC00117
Entry
RC00117                     RClass                                 
Definition
C1c-C5a:*-*:C1a+C1b+O1a-C1a+C1b+O5a
Reactant pair
C00164_C01089    C00164_C03197    C00332_C01144
C00332_C03561    C00332_C05116    C00583_C05235
C01888_C03194    C03505_C03894    C04618_C05744
C07287_C07288    C11404_C11405    C11417_C11419
C11496_C11497    C11497_C11498    C12415_C12418
C16649_C16655    C20500_C20502    C20501_C20502
Related class
Reaction
R01361 R01975 R01976 R01977 R03225 R03759 R04236 R04533
R05576 R05678 R05689 R05690 R06394 R06395 R06678 R08330
R10310 R10311 R10717
Enzyme
1.1.1.6         1.1.1.7         1.1.1.30        1.1.1.35        
1.1.1.36        1.1.1.75        1.1.1.100       1.1.1.157       
1.1.1.260       1.1.1.268       1.1.1.269       1.1.1.352       
1.1.1.-         1.1.99.24       2.3.1.85        2.3.1.86        
2.3.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn00071  Fatty acid degradation
rn00254  Aflatoxin biosynthesis
rn00260  Glycine, serine and threonine metabolism
rn00310  Lysine degradation
rn00362  Benzoate degradation
rn00380  Tryptophan metabolism
rn00630  Glyoxylate and dicarboxylate metabolism
rn00640  Propanoate metabolism
rn00650  Butanoate metabolism
rn00720  Other carbon fixation pathways
rn00903  Limonene degradation
rn00982  Drug metabolism - cytochrome P450
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
rn01220  Degradation of aromatic compounds
RModule
RM017  Ring cleavage via Baeyer-Villiger oxidation
RM018  Beta oxidation in acyl-CoA degradation
RM020  Fatty acid synthesis using acetyl-CoA (reversal of RM018)
RM021  Fatty acid synthesis using malonyl-CoA
Orthology
K00005  glycerol dehydrogenase [EC:1.1.1.6]
K00019  3-hydroxybutyrate dehydrogenase [EC:1.1.1.30]
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00023  acetoacetyl-CoA reductase [EC:1.1.1.36]
K00059  3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
K00074  3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]
K00665  fatty acid synthase, animal type [EC:2.3.1.85]
K00667  fatty acid synthase subunit alpha, fungi type [EC:2.3.1.86]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
K11533  fatty acid synthase, bacteria type [EC:2.3.1.-]
K11539  carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1.-]
K15016  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35]
K17652  5'-hydroxyaverantin dehydrogenase [EC:1.1.1.352]

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