KEGG   REACTION: R01978
Entry
R01978                      Reaction                               
Name
acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Definition
(S)-3-Hydroxy-3-methylglutaryl-CoA + CoA <=> Acetyl-CoA + H2O + Acetoacetyl-CoA
Equation
Comment
possibly two-step reaction (acetoacetyl-CoA-lyase, thioester-hydrolysing)
Reaction class
RC00004  C00010_C00024
RC00503  C00332_C00356
Enzyme
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00650  Butanoate metabolism
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00088  Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone
M00095  C5 isoprenoid biosynthesis, mevalonate pathway
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Orthology
K01641  hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
Other DBs
RHEA: 10191
LinkDB

KEGG   RCLASS: RC00503
Entry
RC00503                     RClass                                 
Definition
C1d-C5a:C1b-*:C1a+C1b+O1a-C1a+C1b+O5a
Reactant pair
Related class
Reaction
Enzyme
2.3.3.10        4.1.3.4
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00650  Butanoate metabolism
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K01640  hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]
K01641  hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]

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