KEGG   REACTION: R02736
Entry
R02736                      Reaction                               
Name
beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase
Definition
beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
Equation
C01172 + C00006 <=> C01236 + C00005 + C00080
Comment
irreversible
Reaction class
RC00001  C00005_C00006
RC00066  C01172_C01236
Enzyme
1.1.1.49        1.1.1.363
Pathway
rn00030  Pentose phosphate pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00004  Pentose phosphate pathway (Pentose phosphate cycle)
M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.49
     R02736  beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
    1.1.1.363
     R02736  beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.49
   R00835  D-Glucose 6-phosphate
    R02736  beta-D-Glucose 6-phosphate
  1.1.1.363
   R00835  D-Glucose 6-phosphate
    R02736  beta-D-Glucose 6-phosphate
Orthology
K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
K13937  hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]
Reference
1  [PMID:14275652]
  Authors
SALAS M, VINUELA E, SOLS A.
  Title
SPONTANEOUS AND ENZYMATICALLY CATALYZED ANOMERIZATION OF GLUCOSE 6-PHOSPHATE AND  ANOMERIC SPECIFICITY OF RELATED ENZYMES.
  Journal
J Biol Chem 240:561-8 (1965)
Reference
2  [PMID:11457850]
  Authors
Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F.
  Title
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase.
  Journal
J Biol Chem 276:34840-6 (2001)
DOI:10.1074/jbc.M105174200
Reference
3  [PMID:9485426]
  Authors
Cosgrove MS, Naylor C, Paludan S, Adams MJ, Levy HR
  Title
On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.
  Journal
Biochemistry 37:2759-67 (1998)
DOI:10.1021/bi972069y
LinkDB

KEGG   RCLASS: RC00001
Entry
RC00001                     RClass                                 
Definition
C1x-C8x:*-*:C2x+C2y-C8x+C8y
N1y-N5y:*-*:C1y+C2x+C2x-C1y+C8x+C8x
Reactant pair
C00003_C00004    C00005_C00006
Related class
Reaction
R00090 R00112 R00267 R00282 R01528 R02034 R02163 R02736
R07141 R07171 R07172 R10517 R10518 R12579 R13176
Enzyme
1.1.1.42        1.1.1.43        1.1.1.44        1.1.1.49        
1.1.1.285       1.1.1.351       1.1.1.363       1.6.1.1         
1.6.1.3         1.6.3.1         1.6.3.2         1.6.3.3         
1.6.3.4         1.6.5.9         1.6.99.1        1.11.1.1        
1.11.1.26       7.1.1.1
Pathway
rn00480  Glutathione metabolism
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
K00032  phosphogluconate 2-dehydrogenase [EC:1.1.1.43]
K00033  6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]
K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
K00322  NAD(P) transhydrogenase [EC:1.6.1.1]
K00323  proton-translocating NAD(P)+ transhydrogenase [EC:7.1.1.1]
K00324  proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]
K00325  proton-translocating NAD(P)+ transhydrogenase subunit beta [EC:7.1.1.1]
K00354  NADPH2 dehydrogenase [EC:1.6.99.1]
K13937  hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]
K22374  3''-deamino-3''-oxonicotianamine reductase [EC:1.1.1.285]

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