KEGG   REACTION: R02874
Entry
R02874                      Reaction                               
Name
squalene,NADPH-hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)
Definition
Squalene + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> (S)-2,3-Epoxysqualene + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00751 + C00007 + C03024 <=> C01054 + C03161 + C00001
Reaction class
RC00201  C00751_C01054
Enzyme
1.14.14.17
Pathway
rn00100  Steroid biosynthesis
rn00909  Sesquiterpenoid and triterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, FPP => cholesterol
M00102  Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.17
     R02874  Squalene + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> (S)-2,3-Epoxysqualene + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K00511  squalene monooxygenase [EC:1.14.14.17]
Other DBs
RHEA: 25285
LinkDB

KEGG   RCLASS: RC00201
Entry
RC00201                     RClass                                 
Definition
C1y-C2b:O2x-*:C1b+C1z-C1b+C2c
C1z-C2c:O2x-*:C1a+C1a+C1y-C1a+C1a+C2b
Reactant pair
C00751_C01054    C09694_C16503    C16502_C16504
C20527_C20529
Related class
Reaction
R02874 R08148 R10351 R10925 R12355
Enzyme
1.14.13.-       1.14.14.17      1.14.14.127     1.14.14.128     
1.14.19.-
Pathway
rn00100  Steroid biosynthesis
rn00403  Indole diterpene alkaloid biosynthesis
rn00909  Sesquiterpenoid and triterpenoid biosynthesis
rn00981  Insect hormone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00511  squalene monooxygenase [EC:1.14.14.17]
K14937  methyl farnesoate epoxidase / farnesoate epoxidase [EC:1.14.14.127 1.14.14.128]
K18386  FAD dependent monooxygenase [EC:1.14.13.-]
K23485  alternative squalene epoxidase [EC:1.14.19.-]

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