KEGG   REACTION: R03026
Entry
R03026                      Reaction                               
Name
(S)-3-hydroxybutanoyl-CoA hydro-lyase
Definition
(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O
Equation
C01144 <=> C00877 + C00001
Reaction class
RC00831  C00877_C01144
Enzyme
4.2.1.17
Pathway
rn00071  Fatty acid degradation
rn00310  Lysine degradation
rn00362  Benzoate degradation
rn00380  Tryptophan metabolism
rn00627  Aminobenzoate degradation
rn00650  Butanoate metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00087  beta-Oxidation
M00374  Dicarboxylate-hydroxybutyrate cycle
M00375  Hydroxypropionate-hydroxybutylate cycle
M00957  Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17
     R03026  (S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O
IUBMB reaction hierarchy [BR:br08202]
 4. Lyase reactions
  4.2.1.17
   R02685  (3S)-3-Hydroxyacyl-CoA <=> trans-2,3-Dehydroacyl-CoA
    R03026  (S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA
Overall reaction [br08210.html]
 Carbon fixation
  R03026
Orthology
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01715  enoyl-CoA hydratase [EC:4.2.1.17]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
K13767  enoyl-CoA hydratase [EC:4.2.1.17]
K15016  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35]
Other DBs
RHEA: 26561
LinkDB

KEGG   RCLASS: RC00831
Entry
RC00831                     RClass                                 
Definition
C1b-C2b:*-*:C1c+C5a-C2b+C5a
C1c-C2b:O1a-*:C1a+C1b-C1a+C2b
Reactant pair
C00877_C01144    C00877_C03561    C00877_C05116
C04246_C04618
Related class
Reaction
R03026 R03027 R04428 R05595
Enzyme
2.3.1.85        2.3.1.86        2.3.1.-         4.2.1.17        
4.2.1.55        4.2.1.59        4.2.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn00071  Fatty acid degradation
rn00310  Lysine degradation
rn00362  Benzoate degradation
rn00380  Tryptophan metabolism
rn00627  Aminobenzoate degradation
rn00630  Glyoxylate and dicarboxylate metabolism
rn00650  Butanoate metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
RModule
RM018  Beta oxidation in acyl-CoA degradation
RM020  Fatty acid synthesis using acetyl-CoA (reversal of RM018)
RM021  Fatty acid synthesis using malonyl-CoA
Orthology
K00665  fatty acid synthase, animal type [EC:2.3.1.85]
K00668  fatty acid synthase subunit beta, fungi type [EC:2.3.1.86]
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01715  enoyl-CoA hydratase [EC:4.2.1.17]
K01716  3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K02372  3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
K11533  fatty acid synthase, bacteria type [EC:2.3.1.-]
K13767  enoyl-CoA hydratase [EC:4.2.1.17]
K15016  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35]
K16363  UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59]
K17865  3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55]
K22540  3-hydroxyacyl-thioester dehydratase, animal type [EC:4.2.1.-]
K22541  3-hydroxyacyl-thioester dehydratase, fungi type [EC:4.2.1.-]

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