KEGG   REACTION: R03171
Entry
R03171                      Reaction                               
Name
(S)-3-methyl-2-oxopentanoate:NAD+ 2-oxidoreductase (CoA-methylbutanoylating)
Definition
(S)-3-Methyl-2-oxopentanoic acid + CoA + NAD+ <=> (S)-2-Methylbutanoyl-CoA + CO2 + NADH + H+
Equation
Comment
multienzyme system: ec 1.2.4.4, ec 2.3.1.168 and ec 1.8.1.4
multi-step reaction (see R04225+R03174+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C15980
RC02856  C00671_C15980
Enzyme
Pathway
rn01210  2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.25
     R03171  (S)-3-Methyl-2-oxopentanoic acid + CoA + NAD+ <=> (S)-2-Methylbutanoyl-CoA + CO2 + NADH + H+
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K09699  2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
Other DBs
RHEA: 30910
LinkDB

KEGG   REACTION: R08567
Entry
R08567                      Reaction                               
Name
(S)-3-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylbutanoylating)
Definition
(S)-3-Methyl-2-oxopentanoic acid + CoA + 2 Oxidized ferredoxin <=> (S)-2-Methylbutanoyl-CoA + CO2 + 2 Reduced ferredoxin + H+
Equation
Reaction class
RC00004  C00010_C15980
RC02856  C00671_C15980
Enzyme
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn01100  Metabolic pathways
rn01210  2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.7  With an iron-sulfur protein as acceptor
    1.2.7.7
     R08567  (S)-3-Methyl-2-oxopentanoic acid + CoA + 2 Oxidized ferredoxin <=> (S)-2-Methylbutanoyl-CoA + CO2 + 2 Reduced ferredoxin + H+
Orthology
K00186  2-oxoisovalerate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.7]
K00187  2-oxoisovalerate ferredoxin oxidoreductase beta subunit [EC:1.2.7.7]
K00188  2-oxoisovalerate ferredoxin oxidoreductase delta subunit [EC:1.2.7.7]
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
LinkDB

KEGG   RCLASS: RC02856
Entry
RC02856                     RClass                                 
Definition
C5a-C5a:C6a+*-*+S2a:C1c+O5a-C1c+O5a
Reactant pair
Related class
Reaction
Enzyme
1.2.4.4         1.2.7.7
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn01100  Metabolic pathways
rn01210  2-Oxocarboxylic acid metabolism
RModule
RM044  2-Oxocarboxylic acid conversion to its CoA derivative
RM903  Oxidative decarboxylation of 2-oxoacid to form its CoA derivative
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K00186  2-oxoisovalerate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.7]
K00187  2-oxoisovalerate ferredoxin oxidoreductase beta subunit [EC:1.2.7.7]
K00188  2-oxoisovalerate ferredoxin oxidoreductase delta subunit [EC:1.2.7.7]
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]

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